Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 3/20 | 0.46 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.46 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.44 |
| ▸ | UBE2M | P61081 | 1/20 | 0.41 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | RHOA | P61586 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | STS | P08842 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31291136 | 1.00 | TACR1 (0.46) | TACR1USP30GPR119UBE2MDCUN1D1 | |
| SCHEMBL30543872 | 0.95 | TACR1 (0.43) | TACR1USP30GPR119UBE2MDCUN1D1 | |
| SCHEMBL23761152 | 0.91 | USP30 (0.50) | USP30GPR119TGFBR1JAK2JAK1 | |
| SCHEMBL22750409 | 0.90 | USP30 (0.51) | USP30GPR119TGFBR1JAK2JAK1 | |
| SCHEMBL23751518 | 0.90 | USP30 (0.51) | USP30GPR119TGFBR1JAK2JAK1 | |
| SCHEMBL25958877 | 0.90 | TACR1 (0.39) | TACR1USP30GPR119UBE2MDCUN1D1 | |
| SCHEMBL31599008 | 0.88 | USP30 (0.47) | USP30GPR119JAK2JAK1MAPT | |
| SCHEMBL30543854 | 0.85 | USP30 (0.56) | USP30GPR119EPHX2TGFBR1JAK2 | |
| SCHEMBL31599077 | 0.85 | USP30 (0.56) | USP30GPR119EPHX2TGFBR1JAK2 | |
| SCHEMBL25957771 | 0.85 | USP30 (0.56) | USP30GPR119EPHX2TGFBR1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023146785-A1 | PYRROLIDINE COMPOUNDS | ELI LILLY AND COMPANY (US) | 2023-08-03 | — | — | WO | disclosed |