Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 15/20 | 0.81 |
| ▸ | JAK2 | O60674 | 10/20 | 0.81 |
| ▸ | TYK2 | P29597 | 1/20 | 0.81 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Londamocitinib SCHEMBL30018267 | 0.89 | JAK1 (1.00) | JAK1JAK2TYK2 | |
| Londamocitinib SCHEMBL30018109 | 0.89 | JAK1 (1.00) | JAK1JAK2TYK2 | |
| Londamocitinib SCHEMBL20399350 | 0.89 | JAK1 (1.00) | JAK1JAK2TYK2 | |
| Londamocitinib SCHEMBL20399395 | 0.89 | JAK1 (1.00) | JAK1JAK2TYK2 | |
| Londamocitinib SCHEMBL20399407 | 0.89 | JAK1 (1.00) | JAK1JAK2TYK2 | |
| Hydrogen Sulfide SCHEMBL25959601 | 0.88 | JAK1 (0.74) | JAK1JAK2TYK2 | |
| SCHEMBL18662686 | 0.87 | JAK1 (1.00) | JAK1JAK2TYK2 | |
| SCHEMBL29395478 | 0.87 | JAK1 (1.00) | JAK1JAK2TYK2 | |
| SCHEMBL19551082 | 0.87 | JAK1 (1.00) | JAK1JAK2TYK2 | |
| SCHEMBL29391999 | 0.87 | JAK1 (1.00) | JAK1JAK2TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4219470-A1 | JAK1 SELECTIVE INHIBITORS | Astrazeneca AB (SE) | 2023-08-02 | — | — | EP | disclosed |