Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 11/20 | 0.50 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | PRCP | P42785 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9994825 | 0.92 | TRPV1 (0.50) | TRPV1HSD11B1LMNA | |
| SCHEMBL2596062 | 0.88 | TRPV1 (0.46) | TRPV1CNR1CNR2PRCPMALT1 | |
| SCHEMBL12183370 | 0.88 | TRPV1 (0.46) | TRPV1CNR1CNR2PRCPMAPT | |
| SCHEMBL2595523 | 0.86 | USP30 (0.46) | TRPV1CNR1CNR2PRCP | |
| SCHEMBL12026581 | 0.85 | TRPV1 (0.46) | TRPV1CNR1CNR2PRCPMALT1 | |
| SCHEMBL9994730 | 0.81 | TRPV1 (0.50) | TRPV1CNR1CNR2 | |
| SCHEMBL9994552 | 0.79 | PDE10A (0.46) | TRPV1ALDH1A1LMNA | |
| SCHEMBL12026558 | 0.78 | PDE10A (0.44) | ALDH1A1MEN1LMNAMAPTHTT | |
| SCHEMBL9994960 | 0.76 | USP30 (0.45) | PRCP | |
| SCHEMBL9995146 | 0.74 | PDE10A (0.50) | ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2569299-A1 | NITROGEN- HETEROCYCLIC COMPOUNDS AS PHOSPHODIESTERASE 10 INHIBITORS | Amgen Inc. (US) | 2013-03-20 | — | — | EP | disclosed |
| WO-2011143129-A1 | NITROGEN- HETEROCYCLIC COMPOUNDS AS PHOSPHODIESTERASE 10 INHIBITORS | AMGEN INC. (US) | 2011-11-17 | — | — | WO | disclosed |