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SCHEMBL25965288

SCHEMBL25965288

c1ccc(-c2cccc3oc4cc(-c5nc(-n6c7ccccc7c7ccccc76)nc(-n6c7ccccc7c7ccc8c9ccccc9n(-c9ccccc9)c8c76)n5)ccc4c23)cc1

nearest known ligand 0.37

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 1/20 0.33
▸ ATM Q13315 1/20 0.33
▸ L3MBTL1 Q9Y468 1/20 0.33
▸ BACE1 P56817 1/20 0.32
▸ DUSP3 P51452 1/20 0.30
▸ RXFP1 Q9HBX9 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22352422 0.96 KDM4E (0.33) KDM4EATML3MBTL1BACE1DUSP3
SCHEMBL25965313 0.95 PDE10A (0.32) BACE1
SCHEMBL24078536 0.95 BACE1 (0.33) KDM4EATML3MBTL1BACE1
SCHEMBL25965284 0.95 KDM4E (0.33) KDM4EATML3MBTL1BACE1
SCHEMBL25965279 0.95 KDM4E (0.33) KDM4EATML3MBTL1BACE1
SCHEMBL24078593 0.93 KDM4E (0.32) KDM4EATML3MBTL1BACE1
SCHEMBL25965341 0.93 KDM4E (0.32) KDM4EATML3MBTL1BACE1
SCHEMBL24390367 0.93 BACE1 (0.32) KDM4EATML3MBTL1BACE1
SCHEMBL24390278 0.93 BACE1 (0.32) KDM4EATML3MBTL1BACE1
SCHEMBL24078422 0.92 KDM4E (0.33) KDM4EATML3MBTL1BACE1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230255106-A1 ORGANIC ELECTROLUMINESCENT APPARATUS MERCK PATENT GMBH (DE) 2023-08-10 — — US disclosed
US-20230255106-A1 ORGANIC ELECTROLUMINESCENT APPARATUS MERCK PATENT GMBH (DE) 2023-08-10 — — US disclosed