Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 20/20 | 0.45 |
| ▸ | HSP90AB1 | P08238 | 20/20 | 0.45 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.43 |
| ▸ | TRAP1 | Q12931 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2596684 | 0.92 | HSP90AA1 (0.45) | HSP90AA1HSP90AB1HSP90B1TRAP1 | |
| SCHEMBL8931378 | 0.82 | HSP90AB1 (0.46) | HSP90AA1HSP90AB1HSP90B1TRAP1 | |
| SCHEMBL421210 | 0.78 | HSP90AA1 (0.48) | HSP90AA1HSP90AB1HSP90B1TRAP1 | |
| SCHEMBL15940182 | 0.78 | HSP90AA1 (0.48) | HSP90AA1HSP90AB1HSP90B1TRAP1 | |
| SCHEMBL5006358 | 0.78 | HSP90AA1 (0.55) | HSP90AA1HSP90AB1HSP90B1TRAP1 | |
| SCHEMBL3094973 | 0.77 | HSP90AA1 (0.45) | HSP90AA1HSP90AB1HSP90B1TRAP1 | |
| SCHEMBL4740712 | 0.76 | HSP90AA1 (0.75) | HSP90AA1HSP90AB1 | |
| SCHEMBL929652 | 0.75 | HSP90AA1 (0.48) | HSP90AA1HSP90AB1HSP90B1TRAP1 | |
| SCHEMBL4786773 | 0.75 | HSP90AA1 (0.52) | HSP90AA1HSP90AB1 | |
| SCHEMBL421461 | 0.75 | HSP90AA1 (0.52) | HSP90AA1HSP90AB1HSP90B1TRAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011146801-A1 | FORMULATION AND DOSING OF HSP90 INHIBITORY COMPOUNDS | SYNTA PHARMACEUTICALS CORP. (US) | 2011-11-24 | — | — | WO | claimed |
| EP-2054059-A2 | TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY | Synta Pharmaceuticals Corporation (US) | 2009-05-06 | — | — | EP | claimed |
| WO-2008021364-A2 | TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY | SYNTA PHARMACEUTICALS CORP. (US) | 2008-02-21 | — | — | WO | claimed |
| EP-2678014-A2 | PROSTATE CANCER THERAPY WITH HSP90 INHIBITORY COMPOUNDS | Synta Pharmaceuticals Corp. (US) | 2014-01-01 | — | — | EP | disclosed |
| WO-2012141796-A2 | PROSTATE CANCER THERAPY WITH HSP90 INHIBITORY COMPOUNDS | SYNTA PHARMACEUTICALS CORP. (US) | 2012-10-18 | — | — | WO | disclosed |
| WO-2008051416-A2 | COMPOUNDS THAT INHIBIT THE ACTIVITY OF HSP90 FOR TREATING INFECTIONS | SYNTA PHARMACEUTICALS CORP. (US) | 2008-05-02 | — | — | WO | disclosed |