Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 5/20 | 0.40 |
| ▸ | ALOX5AP | P20292 | 6/20 | 0.35 |
| ▸ | FEN1 | P39748 | 6/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 7/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 6/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25953879 | 0.88 | ESR1 (0.39) | ESR1ALOX5APFEN1CYP11B2CYP11B1 | |
| SCHEMBL30479230 | 0.86 | ESR1 (0.48) | ESR1ALOX5APFEN1 | |
| SCHEMBL23355223 | 0.86 | ESR1 (0.48) | ESR1ALOX5APFEN1 | |
| SCHEMBL25332395 | 0.84 | ESR1 (0.39) | ESR1ALOX5APFEN1CYP11B2CYP11B1 | |
| SCHEMBL30479246 | 0.84 | ESR1 (0.39) | ESR1ALOX5APFEN1CYP11B2CYP11B1 | |
| SCHEMBL25953323 | 0.80 | ESR1 (0.49) | ESR1 | |
| SCHEMBL30604773 | 0.80 | ESR1 (0.49) | ESR1 | |
| SCHEMBL25967204 | 0.79 | ESR1 (0.59) | ESR1 | |
| SCHEMBL25952543 | 0.78 | ESR1 (0.48) | ESR1ALOX5APFEN1 | |
| SCHEMBL30479245 | 0.78 | ESR1 (0.47) | ESR1CYP11B2CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023150056-A1 | PROCESSES FOR THE PREPARATION OF SELECTIVE ESTROGEN RECEPTOR DEGRADERS | ELI LILLY AND COMPANY (US) | 2023-08-10 | — | — | WO | disclosed |