Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 5/20 | 0.44 |
| ▸ | PTGES2 | Q9H7Z7 | 11/20 | 0.43 |
| ▸ | PLA2G2A | P14555 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.41 |
| ▸ | PTGES | O14684 | 3/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 4/20 | 0.38 |
| ▸ | PRKCG | P05129 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.38 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23270725 | 0.92 | ALOX5AP (0.44) | ALOX5APPTGES2PLA2G2ACYP1A2CYP3A4 | |
| SCHEMBL25968436 | 0.86 | MEN1 (0.49) | ALOX5APPLA2G2ACYP1A2CYP3A4MAPT | |
| SCHEMBL25968434 | 0.80 | PTGES2 (0.60) | ALOX5APPTGES2PLA2G2ACYP1A2CYP3A4 | |
| SCHEMBL23641197 | 0.79 | MEN1 (0.51) | ALOX5APPTGES2PLA2G2ACYP1A2CYP3A4 | |
| SCHEMBL8561632 | 0.73 | PTGES2 (0.58) | ALOX5APPTGES2PLA2G2ACYP1A2CYP3A4 | |
| SCHEMBL23270736 | 0.72 | PTGES2 (0.60) | ALOX5APPTGES2CYP1A2CYP3A4MAPT | |
| SCHEMBL25967886 | 0.70 | ALOX5AP (0.60) | ALOX5APCYP3A4CYP2C9ALOX5PTGS2 | |
| SCHEMBL25968433 | 0.70 | PTGES2 (0.60) | ALOX5APPTGES2CYP1A2CYP3A4MAPT | |
| SCHEMBL9434490 | 0.70 | PTGES2 (0.78) | ALOX5APPTGES2CYP1A2CYP3A4MAPT | |
| SCHEMBL25968431 | 0.69 | PTGES2 (0.64) | ALOX5APPTGES2CYP1A2CYP3A4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11718614-B2 | Compounds and methods for treatment of hedgehog pathway associated conditions | SUZHOU MEDNES PHARMA TECH CO., LTD. (CN) | 2023-08-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11718614-B2 | Compounds and methods for treatment of hedgehog pathway associated conditions | SHH, GLI1, SMO | ALOX5AP 3783/4885PTGES2 1332/4885PLA2G2A 2277/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.