Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23495168 | 0.94 | MAPT (0.57) | MAPTPOLBKDM4ETP53ALDH1A1 | |
| SCHEMBL23495466 | 0.92 | MAPT (0.57) | MAPTPOLBKDM4ETP53ALDH1A1 | |
| SCHEMBL23495114 | 0.86 | MAPT (0.58) | MAPTPOLBKDM4ETP53ALDH1A1 | |
| SCHEMBL23495201 | 0.85 | POLB (0.69) | MAPTPOLBKDM4ETP53ALDH1A1 | |
| SCHEMBL23495165 | 0.83 | POLB (0.54) | MAPTPOLBKDM4ETP53ALDH1A1 | |
| SCHEMBL23495286 | 0.82 | POLB (0.53) | MAPTPOLBKDM4ETP53ALDH1A1 | |
| SCHEMBL23495128 | 0.81 | POLB (0.49) | MAPTPOLBKDM4ETP53ALDH1A1 | |
| SCHEMBL29436159 | 0.81 | POLB (0.49) | MAPTPOLBKDM4ETP53ALDH1A1 | |
| SCHEMBL23495135 | 0.78 | MAPT (0.54) | MAPTPOLBKDM4EMEN1KMT2A | |
| SCHEMBL23495393 | 0.78 | CYP1A2 (0.51) | MAPTPOLBKDM4ETP53ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3877052-B1 | PYRIDAZINONE COMPOUNDS AND USES THEREOF | EDGEWISE THERAPEUTICS INC (US) | 2023-08-16 | — | — | EP | disclosed |