Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 11/20 | 0.69 |
| ▸ | SCN1A | P35498 | 1/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 10/20 | 0.51 |
| ▸ | SCN5A | Q14524 | 10/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25974872 | 1.00 | SCN9A (0.69) | SCN9ASCN1ACYP3A4SCN5A | |
| SCHEMBL25974852 | 0.97 | SCN9A (0.66) | SCN9ASCN1ACYP3A4SCN5A | |
| SCHEMBL20182512 | 0.97 | SCN9A (0.65) | SCN9ASCN1ACYP3A4SCN5A | |
| SCHEMBL20182515 | 0.93 | SCN9A (0.60) | SCN9ASCN1ACYP3A4SCN5A | |
| SCHEMBL19001234 | 0.93 | SCN9A (0.60) | SCN9ASCN1ACYP3A4SCN5A | |
| SCHEMBL25973550 | 0.90 | SCN9A (0.58) | SCN9ASCN1ACYP3A4SCN5A | |
| SCHEMBL25973514 | 0.87 | SCN9A (0.54) | SCN9ASCN1ACYP3A4SCN5A | |
| SCHEMBL25973524 | 0.87 | SCN9A (0.54) | SCN9ASCN1ACYP3A4SCN5A | |
| SCHEMBL25973567 | 0.87 | SCN9A (0.54) | SCN9ASCN1ACYP3A4SCN5A | |
| SCHEMBL20115642 | 0.86 | SCN9A (0.68) | SCN9ASCN1ACYP3A4SCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3541373-B1 | DIAMINO-ALKYLAMINO-LINKED ARYLSULFONAMIDE COMPOUNDS WITH SELECTIVE ACTIVITY IN VOLTAGE-GATED SODIUM CHANNELS | MERCK SHARP & DOHME LLC (US) | 2023-11-01 | — | — | EP | disclosed |
| EP-3389654-B1 | DIAMINO-ALKYLAMINO-LINKED ARYLSULFONAMIDE COMPOUNDS WITH SELECTIVE ACTIVITY IN VOLTAGE-GATED SODIUM CHANNELS | MERCK SHARP & DOHME LLC (US) | 2023-08-16 | — | — | EP | disclosed |