Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 8/20 | 0.54 |
| ▸ | NPC1 | O15118 | 3/20 | 0.54 |
| ▸ | RAB9A | P51151 | 3/20 | 0.54 |
| ▸ | HTT | P42858 | 5/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 3/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.51 |
| ▸ | RELA | Q04206 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25975177 | 0.93 | MAPT (0.61) | MAPTALDH1A1KDM4EMAPK1MEN1 | |
| SCHEMBL25975056 | 0.93 | MAPT (0.61) | MAPTALDH1A1KDM4EMAPK1MEN1 | |
| SCHEMBL25975025 | 0.92 | MAPT (0.59) | MAPTALDH1A1KDM4EMAPK1MEN1 | |
| SCHEMBL25975238 | 0.88 | MAPT (0.56) | MAPTALDH1A1KDM4EMAPK1HPGD | |
| SCHEMBL25975072 | 0.88 | MAPT (0.56) | MAPTALDH1A1KDM4EMAPK1MEN1 | |
| SCHEMBL25974911 | 0.87 | MAPT (0.55) | MAPTALDH1A1KDM4EMAPK1MEN1 | |
| SCHEMBL13541890 | 0.86 | MAPT (0.55) | MAPTALDH1A1KDM4EMAPK1MEN1 | |
| SCHEMBL25975097 | 0.86 | NPC1 (0.57) | MAPTALDH1A1KDM4EMAPK1MEN1 | |
| SCHEMBL25975420 | 0.85 | KDM4E (0.69) | MAPTALDH1A1KDM4EMAPK1MEN1 | |
| SCHEMBL25975137 | 0.84 | MAPT (0.51) | MAPTALDH1A1KDM4EMAPK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023141866-A1 | PYRAZOLOPYRIMIDINES AS MODULATORS OF SPERMINE OXIDASE | JANSSEN PHARMACEUTICA NV (BE) | 2023-08-03 | — | — | WO | disclosed |