Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 13/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 11/20 | 0.48 |
| ▸ | SCN1A | P35498 | 1/20 | 0.45 |
| ▸ | SCN5A | Q14524 | 8/20 | 0.40 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19000747 | 0.94 | SCN9A (0.49) | SCN9ACYP3A4SCN1ASCN5A | |
| SCHEMBL25973048 | 0.92 | SCN9A (0.46) | SCN9ACYP3A4SCN1ASCN5ASCN8A | |
| SCHEMBL19000630 | 0.91 | SCN9A (0.45) | SCN9ACYP3A4SCN1ASCN5ASCN8A | |
| SCHEMBL20182513 | 0.84 | SCN9A (0.56) | SCN9ACYP3A4SCN1ASCN5A | |
| SCHEMBL20115767 | 0.83 | SCN9A (0.68) | SCN9ACYP3A4SCN1ASCN5A | |
| SCHEMBL18992540 | 0.82 | SCN9A (0.72) | SCN9ACYP3A4SCN1ASCN5ASCN8A | |
| SCHEMBL20586573 | 0.82 | SCN9A (0.72) | SCN9ACYP3A4SCN1ASCN5ASCN8A | |
| SCHEMBL25974852 | 0.82 | SCN9A (0.66) | SCN9ACYP3A4SCN1ASCN5A | |
| SCHEMBL20182512 | 0.81 | SCN9A (0.65) | SCN9ACYP3A4SCN1ASCN5A | |
| SCHEMBL23913156 | 0.81 | SCN9A (0.67) | SCN9ACYP3A4SCN1ASCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3389654-B1 | DIAMINO-ALKYLAMINO-LINKED ARYLSULFONAMIDE COMPOUNDS WITH SELECTIVE ACTIVITY IN VOLTAGE-GATED SODIUM CHANNELS | MERCK SHARP & DOHME LLC (US) | 2023-08-16 | — | — | EP | disclosed |