Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 18/20 | 0.60 |
| ▸ | GUCY1A1 | Q02108 | 2/20 | 0.55 |
| ▸ | GUCY1B1 | Q02153 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25977024 | 1.00 | PDE5A (0.60) | PDE5AGUCY1A1GUCY1B1 | |
| SCHEMBL25975060 | 1.00 | PDE5A (0.60) | PDE5AGUCY1A1GUCY1B1 | |
| SCHEMBL25975212 | 0.91 | PDE5A (0.64) | PDE5AGUCY1A1GUCY1B1 | |
| SCHEMBL25975210 | 0.91 | PDE5A (0.64) | PDE5AGUCY1A1GUCY1B1 | |
| SCHEMBL25976957 | 0.85 | PDE5A (0.59) | PDE5AGUCY1A1GUCY1B1 | |
| SCHEMBL25976404 | 0.85 | PDE5A (0.59) | PDE5AGUCY1A1GUCY1B1 | |
| SCHEMBL25976952 | 0.85 | PDE5A (0.59) | PDE5AGUCY1A1GUCY1B1 | |
| SCHEMBL25977040 | 0.84 | PDE5A (0.58) | PDE5AGUCY1A1GUCY1B1 | |
| SCHEMBL25975218 | 0.84 | PDE5A (0.58) | PDE5AGUCY1A1GUCY1B1 | |
| SCHEMBL25975222 | 0.84 | PDE5A (0.58) | PDE5AGUCY1A1GUCY1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230257398-A1 | PYRIMIDINE-BASED TRICYCLIC COMPOUND AND USE THEREOF | CHIA TAL TIANQING PHARMACEUTICAL GROUP CO., LTD. (CN) | 2023-08-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230257398-A1 | PYRIMIDINE-BASED TRICYCLIC COMPOUND AND USE THEREOF | TYMP, TYMS, DPYD | PDE5A 1421/4885GUCY1A1 2940/4885GUCY1B1 2239/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.