Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.62 |
| ▸ | MEN1 | O00255 | 3/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.62 |
| ▸ | LMNA | P02545 | 3/20 | 0.62 |
| ▸ | RAB9A | P51151 | 2/20 | 0.62 |
| ▸ | GAA | P10253 | 2/20 | 0.62 |
| ▸ | CASP3 | P42574 | 1/20 | 0.62 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.62 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.62 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.62 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.57 |
| ▸ | RELA | Q04206 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2597968 | 1.00 | MAPT (0.62) | MAPTMEN1ALDH1A1KMT2ALMNA | |
| SCHEMBL9339706 | 0.83 | MAPT (0.68) | MAPTMEN1ALDH1A1KMT2ALMNA | |
| SCHEMBL9339697 | 0.83 | MAPT (0.68) | MAPTMEN1ALDH1A1KMT2ALMNA | |
| SCHEMBL499504 | 0.82 | MEN1 (0.67) | MAPTMEN1ALDH1A1KMT2ALMNA | |
| SCHEMBL499505 | 0.82 | MEN1 (0.67) | MAPTMEN1ALDH1A1KMT2ALMNA | |
| SCHEMBL3969826 | 0.81 | MAPT (0.55) | MAPTMEN1ALDH1A1KMT2ALMNA | |
| SCHEMBL3969830 | 0.81 | MAPT (0.55) | MAPTMEN1ALDH1A1KMT2ALMNA | |
| SCHEMBL4462260 | 0.81 | MAPT (0.65) | MAPTMEN1ALDH1A1KMT2ALMNA | |
| SCHEMBL4462257 | 0.81 | MAPT (0.65) | MAPTMEN1ALDH1A1KMT2ALMNA | |
| SCHEMBL2598083 | 0.80 | MAPT (0.63) | MAPTMEN1ALDH1A1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2571843-B1 | IMPROVED PREPARATION OF CHALCONE DERIVATIVES | GENFIT (FR) | 2017-12-27 | — | — | EP | disclosed |
| EP-2571843-B1 | IMPROVED PREPARATION OF CHALCONE DERIVATIVES | GENFIT (FR) | 2017-12-27 | — | — | EP | disclosed |
| US-8765992-B2 | Preparation of chalcone derivatives | GENFIT (FR) | 2014-07-01 | — | — | US | disclosed |
| US-8765992-B2 | Preparation of chalcone derivatives | GENFIT (FR) | 2014-07-01 | — | — | US | disclosed |
| US-8765992-B2 | Preparation of chalcone derivatives | GENFIT (FR) | 2014-07-01 | — | — | US | disclosed |
| US-20130131372-A1 | PREPARATION OF CHALCONE DERIVATIVES | GENFIT (FR) | 2013-05-23 | — | — | US | disclosed |
| US-20130131372-A1 | PREPARATION OF CHALCONE DERIVATIVES | GENFIT (FR) | 2013-05-23 | — | — | US | disclosed |
| US-20130131372-A1 | PREPARATION OF CHALCONE DERIVATIVES | GENFIT (FR) | 2013-05-23 | — | — | US | disclosed |
| EP-2571843-A1 | IMPROVED PREPARATION OF CHALCONE DERIVATIVES | Genfit (FR) | 2013-03-27 | — | — | EP | disclosed |
| WO-2011144579-A1 | IMPROVED PREPARATION OF CHALCONE DERIVATIVES | GENFIT (FR) | 2011-11-24 | — | — | WO | disclosed |
| WO-2011144579-A1 | IMPROVED PREPARATION OF CHALCONE DERIVATIVES | GENFIT (FR) | 2011-11-24 | — | — | WO | disclosed |
| US-7566737-B2 | Combinations of substituted 1,3-diphenylprop-2-en-1-one derivatives with other therapeutically active ingredients | GENFIT (FR) | 2009-07-28 | — | — | US | disclosed |
| US-7566737-B2 | Combinations of substituted 1,3-diphenylprop-2-en-1-one derivatives with other therapeutically active ingredients | GENFIT (FR) | 2009-07-28 | — | — | US | disclosed |
| US-7566737-B2 | Combinations of substituted 1,3-diphenylprop-2-en-1-one derivatives with other therapeutically active ingredients | GENFIT (FR) | 2009-07-28 | — | — | US | disclosed |
| US-20070032543-A1 | Combinations of substituted 1,3-diphenylprop-2-EN-1-one derivatives with other therapeutically active ingredients | GENFIT (FR) | 2007-02-08 | — | — | US | disclosed |
| US-20070032543-A1 | Combinations of substituted 1,3-diphenylprop-2-EN-1-one derivatives with other therapeutically active ingredients | GENFIT (FR) | 2007-02-08 | — | — | US | disclosed |
| US-20070032543-A1 | Combinations of substituted 1,3-diphenylprop-2-EN-1-one derivatives with other therapeutically active ingredients | GENFIT (FR) | 2007-02-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070032543-A1 | Combinations of substituted 1,3-diphenylprop-2-EN-1-one derivatives with other therapeutically active ingredients | PSEN1, BACE1, PSEN2 | MAPT 133/4885MEN1 4017/4885ALDH1A1 355/4885 |
| US-20130131372-A1 | PREPARATION OF CHALCONE DERIVATIVES | SULT1E1, HCCS, STS | MAPT 4724/4885MEN1 2269/4885ALDH1A1 874/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.