Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 14/20 | 0.47 |
| ▸ | GRM5 | P41594 | 2/20 | 0.47 |
| ▸ | MAOA | P21397 | 4/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
| ▸ | HPD | P32754 | 1/20 | 0.42 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2598011 | 1.00 | MAOB (0.47) | MAOBGRM5MAOACYP1A2SLC6A4 | |
| SCHEMBL861068 | 1.00 | MAOB (0.47) | MAOBGRM5MAOACYP1A2SLC6A4 | |
| SCHEMBL861069 | 1.00 | MAOB (0.47) | MAOBGRM5MAOACYP1A2SLC6A4 | |
| SCHEMBL861544 | 0.90 | SLC6A4 (0.45) | MAOBGRM5MAOACYP1A2SLC6A4 | |
| SCHEMBL861545 | 0.90 | SLC6A4 (0.45) | MAOBGRM5MAOACYP1A2SLC6A4 | |
| SCHEMBL2599094 | 0.90 | SLC6A4 (0.45) | MAOBGRM5MAOACYP1A2SLC6A4 | |
| SCHEMBL861098 | 0.86 | GRK2 (0.35) | MAOBGRM5MAOASLC6A4 | |
| SCHEMBL2598987 | 0.86 | GRK2 (0.35) | MAOBGRM5MAOASLC6A4 | |
| SCHEMBL2598985 | 0.86 | GRK2 (0.35) | MAOBGRM5MAOASLC6A4 | |
| SCHEMBL861099 | 0.86 | GRK2 (0.35) | MAOBGRM5MAOASLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2571353-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | AbbVie Inc. (US) | 2013-03-27 | — | — | EP | claimed |
| WO-2011146089-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2011-11-24 | — | — | WO | claimed |
| EP-2571353-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | AbbVie Inc. (US) | 2013-03-27 | — | — | EP | disclosed |
| WO-2011146089-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2011-11-24 | — | — | WO | disclosed |