Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 20/20 | 0.60 |
| ▸ | JAK2 | O60674 | 19/20 | 0.60 |
| ▸ | JAK3 | P52333 | 19/20 | 0.60 |
| ▸ | TYK2 | P29597 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1350929 | 0.83 | JAK2 (0.58) | JAK1JAK2JAK3 | |
| SCHEMBL1351003 | 0.83 | JAK2 (0.58) | JAK1JAK2JAK3 | |
| SCHEMBL1352802 | 0.83 | JAK2 (0.58) | JAK1JAK2JAK3 | |
| SCHEMBL1350986 | 0.82 | JAK3 (0.59) | JAK1JAK2JAK3 | |
| SCHEMBL1350946 | 0.80 | JAK1 (0.57) | JAK1JAK2JAK3TYK2 | |
| SCHEMBL2384376 | 0.80 | JAK1 (0.62) | JAK1JAK2JAK3TYK2 | |
| SCHEMBL1352818 | 0.78 | JAK1 (0.57) | JAK1JAK2JAK3TYK2 | |
| SCHEMBL1353134 | 0.78 | JAK3 (0.70) | JAK1JAK2JAK3 | |
| SCHEMBL1352473 | 0.77 | JAK1 (0.60) | JAK1JAK2JAK3TYK2 | |
| SCHEMBL1369017 | 0.77 | JAK3 (0.55) | JAK1JAK2JAK3TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011144584-A1 | PYRROLOPYRAZINE DERIVATIVES AS SYK AND JAK INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-11-24 | — | — | WO | disclosed |