⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25992129 | 0.86 | SMN1; SMN2 (0.31) | — | |
| SCHEMBL25989012 | 0.85 | SMN1; SMN2 (0.32) | — | |
| SCHEMBL26000688 | 0.85 | — | — | |
| SCHEMBL25994367 | 0.83 | — | — | |
| SCHEMBL26003577 | 0.82 | — | — | |
| SCHEMBL25991597 | 0.81 | SMN1; SMN2 (0.32) | — | |
| SCHEMBL24692395 | 0.81 | — | — | |
| SCHEMBL26025266 | 0.80 | PTGS1 (0.33) | — | |
| SCHEMBL25989571 | 0.79 | — | — | |
| SCHEMBL25937913 | 0.79 | PRKCI (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3820573-B1 | 3-(5-HYDROXY-1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF IKAROS FAMILY ZINC FINGER 2 (IKZF2)-DEPENDENT DISEASES | NOVARTIS AG (CH) | 2023-08-09 | — | — | EP | disclosed |