Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 8/20 | 0.50 |
| ▸ | NRAS | P01111 | 4/20 | 0.50 |
| ▸ | EIF2AK4 | Q9P2K8 | 2/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 5/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.34 |
| ▸ | CCNK | O75909 | 2/20 | 0.34 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.34 |
| ▸ | CDK2 | P24941 | 2/20 | 0.34 |
| ▸ | CDK9 | P50750 | 2/20 | 0.34 |
| ▸ | CDK12 | Q9NYV4 | 2/20 | 0.34 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.34 |
| ▸ | CDK7 | P50613 | 1/20 | 0.32 |
| ▸ | CCNH | P51946 | 1/20 | 0.32 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24231327 | 1.00 | FLT3 (0.50) | FLT3NRASEIF2AK4IRAK4CYP11B1 | |
| SCHEMBL25988951 | 1.00 | FLT3 (0.50) | FLT3NRASEIF2AK4IRAK4CYP11B1 | |
| SCHEMBL25991299 | 1.00 | FLT3 (0.50) | FLT3NRASEIF2AK4IRAK4CYP11B1 | |
| SCHEMBL25991300 | 1.00 | FLT3 (0.50) | FLT3NRASEIF2AK4IRAK4CYP11B1 | |
| SCHEMBL24231381 | 1.00 | FLT3 (0.50) | FLT3NRASEIF2AK4IRAK4CYP11B1 | |
| SCHEMBL25989347 | 0.93 | FLT3 (0.54) | FLT3NRASEIF2AK4IRAK4CYP11B1 | |
| SCHEMBL24231485 | 0.93 | FLT3 (0.52) | FLT3NRASEIF2AK4IRAK4CCNT1 | |
| SCHEMBL25990673 | 0.93 | FLT3 (0.54) | FLT3NRASEIF2AK4IRAK4CYP11B1 | |
| SCHEMBL26359533 | 0.93 | FLT3 (0.54) | FLT3NRASEIF2AK4IRAK4CYP11B1 | |
| SCHEMBL25989345 | 0.93 | FLT3 (0.54) | FLT3NRASEIF2AK4IRAK4CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023150601-A2 | MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2023-08-10 | — | — | WO | disclosed |