Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.35 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.35 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.35 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.35 |
| ▸ | FYN | P06241 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 3/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
| ▸ | MET | P08581 | 1/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | PRKACA | P17612 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.35 |
| ▸ | MST1R | Q04912 | 1/20 | 0.35 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2598948 | 1.00 | PBRM1 (0.36) | PBRM1BRD4CLK4DYRK1BNTRK2 | |
| SCHEMBL860469 | 1.00 | PBRM1 (0.36) | PBRM1BRD4CLK4DYRK1BNTRK2 | |
| SCHEMBL860468 | 1.00 | PBRM1 (0.36) | PBRM1BRD4CLK4DYRK1BNTRK2 | |
| Hydrochloric Acid SCHEMBL20575420 | 0.99 | PBRM1 (0.35) | PBRM1BRD4CLK4DYRK1BNTRK2 | |
| Hydrochloric Acid SCHEMBL861884 | 0.99 | PBRM1 (0.35) | PBRM1BRD4CLK4DYRK1BNTRK2 | |
| Hydrochloric Acid SCHEMBL861883 | 0.99 | PBRM1 (0.35) | PBRM1BRD4CLK4DYRK1BNTRK2 | |
| SCHEMBL1805518 | 0.81 | MAOB (0.36) | METGSK3BNPC1ALDH1A1HPGD | |
| SCHEMBL860636 | 0.81 | BRD4 (0.36) | PBRM1BRD4CLK4DYRK1BNTRK2 | |
| SCHEMBL1805520 | 0.81 | MAOB (0.36) | METGSK3BNPC1ALDH1A1HPGD | |
| SCHEMBL860635 | 0.81 | BRD4 (0.36) | PBRM1BRD4CLK4DYRK1BNTRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2571353-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | AbbVie Inc. (US) | 2013-03-27 | — | — | EP | claimed |
| WO-2011146089-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2011-11-24 | — | — | WO | claimed |