Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 13/20 | 0.62 |
| ▸ | IRAK4 | Q9NWZ3 | 9/20 | 0.51 |
| ▸ | NRAS | P01111 | 3/20 | 0.44 |
| ▸ | CSF1R | P07333 | 3/20 | 0.43 |
| ▸ | KDR | P35968 | 3/20 | 0.43 |
| ▸ | KIT | P10721 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24231386 | 1.00 | FLT3 (0.62) | FLT3IRAK4NRASCSF1RKDR | |
| SCHEMBL24231310 | 0.92 | FLT3 (0.57) | FLT3IRAK4NRASCSF1RKDR | |
| SCHEMBL25991518 | 0.92 | FLT3 (0.57) | FLT3IRAK4NRASCSF1RKDR | |
| SCHEMBL25989838 | 0.92 | FLT3 (0.64) | FLT3IRAK4NRASCSF1RKDR | |
| SCHEMBL24231476 | 0.92 | FLT3 (0.64) | FLT3IRAK4NRASCSF1RKDR | |
| SCHEMBL24231241 | 0.89 | FLT3 (0.60) | FLT3IRAK4NRASCSF1RKDR | |
| SCHEMBL25989836 | 0.89 | FLT3 (0.60) | FLT3IRAK4NRASCSF1RKDR | |
| SCHEMBL24975661 | 0.89 | FLT3 (0.50) | FLT3IRAK4CSF1RKDRKIT | |
| SCHEMBL24231226 | 0.89 | FLT3 (0.62) | FLT3IRAK4NRASCSF1RKDR | |
| SCHEMBL25989788 | 0.89 | FLT3 (0.62) | FLT3IRAK4NRASCSF1RKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023150601-A2 | MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2023-08-10 | — | — | WO | disclosed |