Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 4/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.36 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.33 |
| ▸ | PGR | P06401 | 4/20 | 0.33 |
| ▸ | PIM2 | Q9P1W9 | 3/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.32 |
| ▸ | FYN | P06241 | 1/20 | 0.32 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.32 |
| ▸ | WNT1 | P04628 | 1/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | AKT1 | P31749 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2599078 | 1.00 | PIM1 (0.36) | PIM1CLK4DAPK3NTRK1FLT3 | |
| SCHEMBL860932 | 1.00 | PIM1 (0.36) | PIM1CLK4DAPK3NTRK1FLT3 | |
| SCHEMBL1805029 | 1.00 | PIM1 (0.36) | PIM1CLK4DAPK3NTRK1FLT3 | |
| SCHEMBL1804971 | 0.92 | CLK4 (0.33) | PIM1CLK4DAPK3NTRK1FLT3 | |
| SCHEMBL1804967 | 0.92 | CLK4 (0.33) | PIM1CLK4DAPK3NTRK1FLT3 | |
| SCHEMBL1804970 | 0.92 | CLK4 (0.33) | PIM1CLK4DAPK3NTRK1FLT3 | |
| SCHEMBL1804240 | 0.91 | PIM1 (0.47) | PIM1CLK4DAPK3NTRK1FLT3 | |
| SCHEMBL1804237 | 0.91 | PIM1 (0.47) | PIM1CLK4DAPK3NTRK1FLT3 | |
| SCHEMBL1804241 | 0.91 | PIM1 (0.47) | PIM1CLK4DAPK3NTRK1FLT3 | |
| SCHEMBL2599125 | 0.89 | HRH3 (0.38) | PIM1CLK4MEN1KMT2AGRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2571353-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | AbbVie Inc. (US) | 2013-03-27 | — | — | EP | disclosed |
| WO-2011146089-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2011-11-24 | — | — | WO | disclosed |