SCHEMBL2599121

SCHEMBL2599121

CN1CC2CNC(=O)c3cc(-c4ccc(F)cc4)ccc3C2C1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HRH3 Q9Y5N1 2/20 0.38
PARP1 P09874 3/20 0.34
GRM2 Q14416 1/20 0.34
MEN1 O00255 1/20 0.34
MAPK1 P28482 1/20 0.34
KMT2A Q03164 1/20 0.34
PARP10 Q53GL7 2/20 0.33
PARP11 Q9NR21 1/20 0.33
PIM1 P11309 1/20 0.33
CYP2D6 P10635 3/20 0.33
CYP3A4 P08684 2/20 0.33
HSD17B2 P37059 1/20 0.33
HDAC2 Q92769 1/20 0.33
MC4R P32245 1/20 0.32
MC5R P33032 1/20 0.32
HTR1A P08908 1/20 0.32
HTR1D P28221 1/20 0.32
HTR1F P30939 1/20 0.32
CLK4 Q9HAZ1 2/20 0.32
DYRK1B Q9Y463 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2599125 1.00 HRH3 (0.38) HRH3PARP1GRM2MEN1MAPK1
SCHEMBL860764 1.00 HRH3 (0.38) HRH3PARP1GRM2MEN1MAPK1
SCHEMBL861567 1.00 HRH3 (0.38) HRH3PARP1GRM2MEN1MAPK1
SCHEMBL2598004 0.91 PARP1 (0.39) HRH3PARP1MEN1MAPK1KMT2A
SCHEMBL860851 0.91 PARP1 (0.39) HRH3PARP1MEN1MAPK1KMT2A
SCHEMBL860850 0.91 PARP1 (0.39) HRH3PARP1MEN1MAPK1KMT2A
SCHEMBL2598003 0.91 PARP1 (0.39) HRH3PARP1MEN1MAPK1KMT2A
SCHEMBL861047 0.91 PARP10 (0.44) HRH3GRM2PARP10PARP11PIM1
SCHEMBL861046 0.91 PARP10 (0.44) HRH3GRM2PARP10PARP11PIM1
SCHEMBL1805029 0.89 PIM1 (0.36) HRH3GRM2MEN1KMT2APIM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2571353-A1 MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF AbbVie Inc. (US) 2013-03-27 EP disclosed
WO-2011146089-A1 MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF ABBOTT LABORATORIES (US) 2011-11-24 WO disclosed