Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 9/20 | 0.38 |
| ▸ | HTR2C | P28335 | 9/20 | 0.38 |
| ▸ | HTR2B | P41595 | 9/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | TDP2 | O95551 | 1/20 | 0.33 |
| ▸ | NSD2 | O96028 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.33 |
| ▸ | CES1 | P23141 | 1/20 | 0.33 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.33 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.33 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1802435 | 1.00 | HTR2A (0.38) | HTR2AHTR2CHTR2BCHRNB2CHRNB4 | |
| SCHEMBL2599148 | 1.00 | HTR2A (0.38) | HTR2AHTR2CHTR2BCHRNB2CHRNB4 | |
| SCHEMBL1802438 | 1.00 | HTR2A (0.38) | HTR2AHTR2CHTR2BCHRNB2CHRNB4 | |
| SCHEMBL862455 | 0.76 | HTR2C (0.59) | HTR2AHTR2CHTR2BCHRNB4CHRNA3 | |
| SCHEMBL14889471 | 0.76 | HTR2C (0.59) | HTR2AHTR2CHTR2BCHRNB4CHRNA3 | |
| SCHEMBL852283 | 0.76 | HTR2C (0.59) | HTR2AHTR2CHTR2BCHRNB4CHRNA3 | |
| SCHEMBL2599038 | 0.76 | HTR2C (0.59) | HTR2AHTR2CHTR2BCHRNB4CHRNA3 | |
| SCHEMBL860175 | 0.76 | HTR2C (0.59) | HTR2AHTR2CHTR2BCHRNB4CHRNA3 | |
| SCHEMBL851893 | 0.76 | HTR2C (0.59) | HTR2AHTR2CHTR2BCHRNB4CHRNA3 | |
| SCHEMBL852284 | 0.76 | HTR2C (0.59) | HTR2AHTR2CHTR2BCHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2571353-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | AbbVie Inc. (US) | 2013-03-27 | — | — | EP | disclosed |
| WO-2011146089-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2011-11-24 | — | — | WO | disclosed |