Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDR1 | Q08345 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 2/20 | 0.32 |
| ▸ | CA9 | Q16790 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | AR | P10275 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MPO | P05164 | 1/20 | 0.31 |
| ▸ | XDH | P47989 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2597158 | 0.85 | DDR1 (0.36) | DDR1CA12CA9ARMPO | |
| SCHEMBL2599374 | 0.83 | DDR1 (0.39) | DDR1CA12CA9KDM4EHSD17B10 | |
| SCHEMBL1661191 | 0.82 | DDR1 (0.35) | DDR1CA12CA9AR | |
| SCHEMBL2597309 | 0.78 | DDR1 (0.35) | DDR1CA12CA9KDM4EHSD17B10 | |
| SCHEMBL958028 | 0.77 | DDR1 (0.35) | DDR1CA12CA9AR | |
| SCHEMBL1001067 | 0.77 | DDR1 (0.36) | DDR1CA12CA9KDM4EALDH1A1 | |
| SCHEMBL2597153 | 0.77 | DDR1 (0.35) | DDR1CA12CA9KDM4EHSD17B10 | |
| SCHEMBL1661057 | 0.76 | AR (0.36) | DDR1CA12CA9ARLMNA | |
| SCHEMBL2597372 | 0.76 | KDM4E (0.36) | DDR1CA12CA9KDM4EHSD17B10 | |
| SCHEMBL12180486 | 0.76 | DDR1 (0.36) | DDR1CA12CA9KDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2571865-A1 | 2,4-DIOXO-1,4-DIHYDRO-2H-QUINAZOLIN-3-YL-SULFONAMIDE DERIVATIVES | Novartis AG (CH) | 2013-03-27 | — | — | EP | disclosed |
| WO-2011144666-A1 | 2,4-DIOXO-1,4-DIHYDRO-2H-QUINAZOLIN-3-YL-SULFONAMIDE DERIVATIVES | NOVARTIS AG (CH) | 2011-11-24 | — | — | WO | disclosed |