Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K4 | P45985 | 2/20 | 0.59 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.42 |
| ▸ | ELANE | P08246 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 2/20 | 0.35 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.35 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25994433 | 0.88 | MAP2K4 (0.56) | MAP2K4ELANESMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL22801612 | 0.87 | MAP2K4 (0.77) | MAP2K4RIPK2ELANEKDRCSNK1D | |
| SCHEMBL25994506 | 0.87 | MAP2K4 (0.56) | MAP2K4RIPK2ELANESMN1; SMN2KDM4E | |
| SCHEMBL22801564 | 0.85 | MAP2K4 (0.55) | MAP2K4RIPK2ELANENR1H2 | |
| SCHEMBL25994507 | 0.85 | MAP2K4 (0.55) | MAP2K4RIPK2ELANEGPR119NPC1 | |
| SCHEMBL4006762 | 0.84 | MAP2K4 (0.58) | MAP2K4ELANESMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL2860870 | 0.84 | MAP2K4 (0.61) | MAP2K4RIPK2ELANEKDRCSNK1D | |
| SCHEMBL22801842 | 0.83 | MAP2K4 (0.52) | MAP2K4ELANEGPR119NPC1MAPT | |
| SCHEMBL22801881 | 0.82 | MAP2K4 (0.50) | MAP2K4ELANEKDRRETNR1H2 | |
| SCHEMBL22801557 | 0.81 | MAP2K4 (0.60) | MAP2K4RIPK2ELANEGPR119KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11731953-B2 | Methods and compounds for restoring mutant p53 function | PMV PHARMACEUTICALS, INC. (US) | 2023-08-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11731953-B2 | Methods and compounds for restoring mutant p53 function | TP53, TP53BP1, HRAS | MAP2K4 3056/4885RIPK2 2353/4885ELANE 1923/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.