Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
| ▸ | DRD4 | P21917 | 4/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | HTR2C | P28335 | 2/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 3/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25359715 | 0.92 | DRD4 (0.48) | SIGMAR1DRD4DRD2HTR2CDRD3 | |
| SCHEMBL26004166 | 0.92 | DRD4 (0.48) | SIGMAR1DRD4DRD2HTR2CDRD3 | |
| SCHEMBL26004506 | 0.90 | DRD4 (0.42) | SIGMAR1DRD4DRD2HTR2CDRD3 | |
| SCHEMBL25359584 | 0.88 | DRD4 (0.43) | SIGMAR1DRD4DRD2HTR2CDRD3 | |
| SCHEMBL26004283 | 0.88 | DRD4 (0.43) | SIGMAR1DRD4DRD2HTR2CDRD3 | |
| SCHEMBL25356661 | 0.87 | MAPK1 (0.45) | SIGMAR1DRD4DRD2HTR2CDRD3 | |
| SCHEMBL26005043 | 0.87 | MAPK1 (0.45) | SIGMAR1DRD4DRD2HTR2CDRD3 | |
| SCHEMBL26012483 | 0.86 | DRD4 (0.45) | DRD4DRD2HTR2CDRD3KMT2A | |
| SCHEMBL26004216 | 0.83 | MEN1 (0.48) | SIGMAR1DRD4DRD2HTR2CDRD3 | |
| SCHEMBL26014425 | 0.83 | DRD4 (0.43) | SIGMAR1DRD4DRD2HTR2CDRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023154314-A1 | SPIRO PIPERIDINE DERIVATIVES AS INHIBITORS OF APOL1 AND METHODS OF USING SAME | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2023-08-17 | — | — | WO | disclosed |