Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | CD38 | P28907 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CCNC | P24863 | 1/20 | 0.43 |
| ▸ | CDK8 | P49336 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | KRAS | P01116 | 1/20 | 0.41 |
| ▸ | FBP1 | P09467 | 1/20 | 0.41 |
| ▸ | GALR3 | O60755 | 1/20 | 0.40 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 3/20 | 0.40 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.40 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.38 |
| ▸ | FLT1 | P17948 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | PRNP | P04156 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13283265 | 0.85 | HTT (0.69) | HTTLMNASMN1; SMN2CD38TP53 | |
| SCHEMBL13283199 | 0.79 | GALR3 (0.63) | HTTLMNASMN1; SMN2GAAGALR3 | |
| SCHEMBL4572178 | 0.79 | GALR3 (0.63) | HTTLMNASMN1; SMN2GAAGALR3 | |
| SCHEMBL24576524 | 0.78 | GALR3 (0.70) | LMNAKRASGALR3NR2F2EGFR | |
| SCHEMBL31505709 | 0.78 | GALR3 (0.70) | LMNAKRASGALR3NR2F2EGFR | |
| SCHEMBL24577013 | 0.78 | GALR3 (0.70) | LMNAKRASGALR3NR2F2EGFR | |
| SCHEMBL29775126 | 0.78 | GALR3 (0.70) | LMNAKRASGALR3NR2F2EGFR | |
| SCHEMBL7804103 | 0.77 | CYP1A2 (0.54) | HTTLMNASMN1; SMN2CCNCCDK8 | |
| SCHEMBL13283195 | 0.76 | MAP4K4 (0.48) | HTTLMNASMN1; SMN2CD38CCNC | |
| SCHEMBL24576686 | 0.76 | EGFR (0.65) | HTTLMNASMN1; SMN2KRASGALR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023154124-A1 | ACYLATED HETEROCYCLIC QUINAZOLINE DERIVATIVES AS INHIBITORS OF ERBB2 | ENLIVEN THERAPEUTICS, INC. (US) | 2023-08-17 | — | — | WO | disclosed |