⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18327050 | 1.00 | — | — | |
| SCHEMBL2614325 | 1.00 | — | — | |
| SCHEMBL17545823 | 0.93 | — | — | |
| SCHEMBL21969664 | 0.93 | — | — | |
| SCHEMBL10267353 | 0.86 | CYP2D6 (0.32) | — | |
| SCHEMBL18531920 | 0.86 | CYP2D6 (0.32) | — | |
| SCHEMBL1708842 | 0.86 | CYP2D6 (0.32) | — | |
| SCHEMBL10197388 | 0.86 | CYP2D6 (0.32) | — | |
| SCHEMBL24850605 | 0.83 | — | — | |
| SCHEMBL13629197 | 0.83 | GAA (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240067656-A1 | COMPOSITIONS AND METHODS FOR TREATING CANCER | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2024-02-29 | — | — | US | disclosed |
| US-20230248730-A1 | USE OF INHIBITORS OF BRUTONS TYROSINE KINASE (BTK) | PHARMACYCLICS LLC (US) | 2023-08-10 | — | — | US | disclosed |
| US-11672803-B2 | Use of inhibitors of Brutons tyrosine kinase (Btk) | PHARMACYCLICS LLC (US) | 2023-06-13 | — | — | US | disclosed |
| US-10023588-B2 | Compositions and methods for treating cancer | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2018-07-17 | — | — | US | disclosed |
| US-20160368930-A1 | COMPOSITIONS AND METHODS FOR TREATING CANCER | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2016-12-22 | — | — | US | disclosed |
| US-20160324859-A1 | USE OF INHIBITORS OF BRUTON'S TYROSINE KINASE (BTK) | PHARMACYCLICS, INC. | 2016-11-10 | — | — | US | disclosed |
| US-8999999-B2 | Use of inhibitors of Bruton's tyrosine kinase (Btk) | PHARMACYCLICS, INC. (US) | 2015-04-07 | — | — | US | disclosed |
| US-20150031710-A1 | USE OF INHIBITORS OF BRUTON'S TYROSINE KINASE (BTK) | PHARMACYCLICS, INC. (US) | 2015-01-29 | — | — | US | disclosed |
| US-20130202611-A1 | USE OF INHIBITORS OF BRUTON'S TYROSINE KINASE (BTK) | PHARMACYCLICS, INC. (US) | 2013-08-08 | — | — | US | disclosed |
| US-20130195852-A1 | USE OF INHIBITORS OF BRUTON'S TYROSINE KINASE (BTK) | PHARMACYCLICS, INC. (US) | 2013-08-01 | — | — | US | disclosed |
| US-20120100138-A1 | THE USE OF INHIBITORS OF BRUTON'S TYROSINE KINASE (BTK) | PHARMACYCLICS, INC. (US) | 2012-04-26 | — | — | US | disclosed |