Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 20/20 | 0.83 |
| ▸ | CNR2 | P34972 | 4/20 | 0.77 |
| ▸ | TACR2 | P21452 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21881217 | 1.00 | CNR1 (0.83) | CNR1CNR2TACR2 | |
| SCHEMBL31267260 | 1.00 | CNR1 (0.83) | CNR1CNR2TACR2 | |
| SCHEMBL470296 | 1.00 | CNR1 (0.83) | CNR1CNR2TACR2 | |
| SCHEMBL1491756 | 1.00 | CNR1 (0.83) | CNR1CNR2TACR2 | |
| SCHEMBL10031415 | 1.00 | CNR1 (0.83) | CNR1CNR2TACR2 | |
| SCHEMBL2128634 | 1.00 | CNR1 (0.83) | CNR1CNR2TACR2 | |
| SCHEMBL470303 | 1.00 | CNR1 (0.83) | CNR1CNR2TACR2 | |
| Water SCHEMBL30514586 | 0.99 | CNR1 (0.82) | CNR1CNR2TACR2 | |
| Water SCHEMBL30514585 | 0.99 | CNR1 (0.82) | CNR1CNR2TACR2 | |
| SCHEMBL9932180 | 0.91 | CNR1 (1.00) | CNR1CNR2TACR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2613785-B1 | HETEROARYLMETHYL AMIDES | HOFFMANN LA ROCHE (CH) | 2015-07-29 | — | — | EP | disclosed |
| EP-2475645-B1 | 5-(3,4-DICHLORO-PHENYL)-N-(2-HYDROXY-CYCLOHEXYL)-6-(2,2,2-TRIFLUORO-ETHOXY)-NICOTINAMIDE AND SALTS THEREOF AS HDL CHOLESTEROL RAISING AGENTS | HOFFMANN LA ROCHE (CH) | 2013-07-03 | — | — | EP | disclosed |
| US-8227491-B2 | 5-(3,4-dichloro-phenyl)-N-(2-hydroxy-cyclohexyl)-6-(2,2,2-trifluoro-ethoxy)-nicotinamide and salts thereof | HOFFMANN-LA ROCHE INC. (US) | 2012-07-24 | — | — | US | disclosed |
| US-8227491-B2 | 5-(3,4-dichloro-phenyl)-N-(2-hydroxy-cyclohexyl)-6-(2,2,2-trifluoro-ethoxy)-nicotinamide and salts thereof | HOFFMANN-LA ROCHE INC. (US) | 2012-07-24 | — | — | US | disclosed |
| US-8227491-B2 | 5-(3,4-dichloro-phenyl)-N-(2-hydroxy-cyclohexyl)-6-(2,2,2-trifluoro-ethoxy)-nicotinamide and salts thereof | HOFFMANN-LA ROCHE INC. (US) | 2012-07-24 | — | — | US | disclosed |
| US-20120101282-A1 | PROCESS FOR THE PREPARATION OF NICOTINAMIDE DERIVATIVES | HOFFMANN-LA ROCHE INC. | 2012-04-26 | — | — | US | disclosed |
| US-20120101282-A1 | PROCESS FOR THE PREPARATION OF NICOTINAMIDE DERIVATIVES | HOFFMANN-LA ROCHE INC. | 2012-04-26 | — | — | US | disclosed |
| WO-2011029827-A1 | 5- (3, 4-DICHLORO-PHENYL) -N- (2-HYDROXY-CYCLOHEXYL) -6- (2,2, 2-TRIFLUORO-ETHOXY) -NICO TINAMIDE AND SALTS THEREOF AS HDL CHOLESTEROL RAISING AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-03-17 | — | — | WO | disclosed |
| US-20110065759-A1 | 5-(3,4-DICHLORO-PHENYL)-N-(2-HYDROXY-CYCLOHEXYL)-6-(2,2,2-TRIFLUORO-ETHOXY)-NICOTINAMIDE AND SALTS THEREOF | HOFFMANN-LA ROCHE, INC. | 2011-03-17 | — | — | US | disclosed |
| US-20110065759-A1 | 5-(3,4-DICHLORO-PHENYL)-N-(2-HYDROXY-CYCLOHEXYL)-6-(2,2,2-TRIFLUORO-ETHOXY)-NICOTINAMIDE AND SALTS THEREOF | HOFFMANN-LA ROCHE, INC. | 2011-03-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120101282-A1 | PROCESS FOR THE PREPARATION OF NICOTINAMIDE DERIVATIVES | CNR1, CNR2, NAMPT | CNR1 1/4885CNR2 2/4885TACR2 211/4885 |
| US-20110065759-A1 | 5-(3,4-DICHLORO-PHENYL)-N-(2-HYDROXY-CYCLOHEXYL)-6-(2,2,2-TRIFLUORO-ETHOXY)-NICOTINAMIDE AND SALTS THEREOF | NNT, PCSK9, NADK | CNR1 679/4885CNR2 299/4885TACR2 2883/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.