Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 7/20 | 0.54 |
| ▸ | IKZF2 | Q9UKS7 | 9/20 | 0.47 |
| ▸ | WIZ | O95785 | 3/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26028088 | 0.99 | CRBN (0.53) | CRBNIKZF2WIZHRH3 | |
| SCHEMBL26026822 | 0.92 | CRBN (0.46) | CRBNIKZF2WIZHRH3 | |
| SCHEMBL21621860 | 0.89 | CRBN (0.68) | CRBNIKZF2WIZ | |
| SCHEMBL21621991 | 0.88 | CRBN (0.67) | CRBNIKZF2WIZ | |
| SCHEMBL21621728 | 0.88 | CRBN (0.67) | CRBNIKZF2WIZ | |
| SCHEMBL24079598 | 0.87 | CRBN (0.68) | CRBNIKZF2WIZ | |
| SCHEMBL24692419 | 0.86 | PRMT5 (0.45) | CRBNIKZF2WIZ | |
| SCHEMBL25993290 | 0.84 | CRBN (0.55) | CRBNIKZF2WIZ | |
| SCHEMBL26000355 | 0.83 | CRBN (0.54) | CRBNIKZF2WIZ | |
| SCHEMBL26254650 | 0.82 | IKZF2 (0.59) | CRBNIKZF2WIZ |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3820573-B1 | 3-(5-HYDROXY-1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF IKAROS FAMILY ZINC FINGER 2 (IKZF2)-DEPENDENT DISEASES | NOVARTIS AG (CH) | 2023-08-09 | — | — | EP | disclosed |