Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 5/20 | 0.42 |
| ▸ | MAP4K2 | Q12851 | 6/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.39 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.39 |
| ▸ | SLK | Q9H2G2 | 2/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | INSR | P06213 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | LYN | P07948 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | ROS1 | P08922 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | FER | P16591 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | BLK | P51451 | 1/20 | 0.39 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.39 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.39 |
| ▸ | BTK | Q06187 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26007557 | 0.84 | SYK (0.40) | SYKMAP4K2MAP4K4PKN2AURKB | |
| SCHEMBL26011193 | 0.83 | SYK (0.42) | SYKMAP4K2MAP4K4PKN2AURKB | |
| SCHEMBL26005518 | 0.80 | SYK (0.41) | SYKMAP4K2MAP4K4PKN2AURKB | |
| SCHEMBL3044547 | 0.78 | SYK (0.33) | SYKMAP4K2MAP4K4PKN2AURKB | |
| SCHEMBL26022798 | 0.78 | MAPK1 (0.42) | SYKMAP4K2MAP4K4PKN2AURKB | |
| SCHEMBL13221039 | 0.78 | PAK1 (0.42) | SYK | |
| SCHEMBL26007684 | 0.75 | PDE2A (0.33) | SYKMAP4K2MAP4K4PKN2AURKB | |
| SCHEMBL26035235 | 0.75 | SYK (0.32) | SYKMAP4K2MAP4K4PKN2AURKB | |
| SCHEMBL13220904 | 0.72 | ALK (0.49) | SYKMAP4K2MAP4K4PKN2AURKB | |
| SCHEMBL26009808 | 0.71 | ATR (0.40) | SYKJAK2FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023154426-A1 | CDK INHIBITORS AND METHODS OF USE THEREOF | RELAY THERAPEUTICS, INC. (US) | 2023-08-17 | — | — | WO | disclosed |