Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 16/20 | 0.47 |
| ▸ | GCK | P35557 | 3/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2603675 | 0.89 | MEN1 (0.46) | BRAF | |
| SCHEMBL12615718 | 0.89 | BRAF (0.45) | BRAFPDGFRA | |
| SCHEMBL13610570 | 0.87 | BRAF (0.46) | BRAFPDGFRA | |
| SCHEMBL12616401 | 0.87 | BRAF (0.44) | BRAF | |
| SCHEMBL12616754 | 0.85 | BRAF (0.47) | BRAF | |
| SCHEMBL2603635 | 0.83 | BRAF (0.46) | BRAFGCK | |
| SCHEMBL2603895 | 0.81 | JAK1 (0.43) | BRAF | |
| SCHEMBL12652265 | 0.80 | LYN (0.43) | BRAF | |
| SCHEMBL12615873 | 0.78 | MAP2K1 (0.39) | BRAF | |
| SCHEMBL1796270 | 0.78 | AURKA (0.40) | BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2013207-B1 | IMIDAZO[4,5-B]PYRIDIN-2-ONE COMPOUNDS AND ANALOGS THEREOF AS CANCER THERAPEUTIC COMPOUNDS | CANCER REC TECH LTD (GB) | 2012-04-25 | — | — | EP | disclosed |