Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 3/20 | 0.47 |
| ▸ | DGAT2 | Q96PD7 | 2/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | DGAT1 | O75907 | 3/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | PDE2A | O00408 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | DAO | P14920 | 1/20 | 0.31 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
| ▸ | METAP2 | P50579 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20703524 | 0.84 | IDO1 (0.53) | IDO1DGAT2AURKADGAT1KCNH2 | |
| SCHEMBL30563327 | 0.83 | IDO1 (0.50) | IDO1DGAT2AURKADGAT1KCNH2 | |
| SCHEMBL20703544 | 0.81 | IDO1 (0.50) | IDO1DGAT2AURKADGAT1KCNH2 | |
| SCHEMBL22776769 | 0.78 | IDO1 (0.45) | IDO1DGAT2AURKAHTTHSD17B10 | |
| SCHEMBL20718057 | 0.77 | IDO1 (0.49) | IDO1DGAT2KCNH2PDE2A | |
| SCHEMBL20703572 | 0.77 | IDO1 (0.45) | IDO1DGAT2AURKAPDE2A | |
| SCHEMBL20703944 | 0.75 | IDO1 (0.46) | IDO1DGAT2PDE2A | |
| SCHEMBL20718216 | 0.75 | IDO1 (0.44) | IDO1 | |
| SCHEMBL20703641 | 0.75 | IDO1 (0.47) | IDO1DGAT2HTTALDH1A1POLB | |
| SCHEMBL30563474 | 0.75 | IDO1 (0.44) | IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3661909-B1 | NOVEL SUBSTITUTED PHENYL COMPOUNDS AS INDOLEAMINE 2,3-DIOXYGENASE (IDO) INHIBITORS | MERCK SHARP & DOHME LLC (US) | 2023-08-16 | — | — | EP | disclosed |