Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 17/20 | 0.47 |
| ▸ | DDB1 | Q16531 | 16/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29681670 | 0.87 | CRBN (0.44) | CRBNDDB1POLB | |
| SCHEMBL24206846 | 0.87 | CRBN (0.44) | CRBNDDB1POLB | |
| SCHEMBL31105540 | 0.84 | CRBN (0.47) | CRBNDDB1POLB | |
| SCHEMBL29681916 | 0.83 | CRBN (0.45) | CRBNDDB1POLB | |
| SCHEMBL24206795 | 0.83 | CRBN (0.45) | CRBNDDB1POLB | |
| SCHEMBL27342475 | 0.83 | CRBN (0.45) | CRBNDDB1POLBGAAKMT2A | |
| SCHEMBL26641500 | 0.80 | CRBN (0.39) | CRBNDDB1POLB | |
| SCHEMBL29681716 | 0.80 | CRBN (0.39) | CRBNDDB1POLBGAAKMT2A | |
| SCHEMBL24206814 | 0.80 | CRBN (0.39) | CRBNDDB1POLBGAAKMT2A | |
| SCHEMBL24319159 | 0.80 | DDB1 (0.56) | CRBNDDB1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230265116-A1 | DEGRADATION OF (EGFR) BY CONJUGATION OF EGFR INHIBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE | BEONE MEDICINES I GMBH (CH) | 2023-08-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230265116-A1 | DEGRADATION OF (EGFR) BY CONJUGATION OF EGFR INHIBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE | EGFR, CBL, ERBB2 | CRBN 144/4885DDB1 438/4885POLB 3418/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.