Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.47 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.41 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20129179 | 0.95 | NR1H2 (0.48) | NR1H2PRMT5WDR77USP2SMN1; SMN2 | |
| SCHEMBL20128969 | 0.94 | NR1H2 (0.43) | NR1H2PRMT5WDR77PDE4DPDE4A | |
| SCHEMBL27097799 | 0.90 | NR1H2 (0.43) | NR1H2PRMT5WDR77USP2SMN1; SMN2 | |
| SCHEMBL20129034 | 0.90 | NR1H2 (0.43) | NR1H2PRMT5WDR77USP2SMN1; SMN2 | |
| SCHEMBL16419552 | 0.89 | NR1H2 (0.50) | NR1H2PRMT5WDR77USP2SMN1; SMN2 | |
| SCHEMBL28959326 | 0.88 | NR1H2 (0.50) | NR1H2PRMT5WDR77USP2SMN1; SMN2 | |
| SCHEMBL27097864 | 0.87 | NR1H2 (0.43) | NR1H2PRMT5WDR77USP2SMN1; SMN2 | |
| SCHEMBL26495742 | 0.87 | NR1H2 (0.43) | NR1H2PRMT5WDR77USP2SMN1; SMN2 | |
| SCHEMBL20129252 | 0.87 | NR1H2 (0.43) | NR1H2PRMT5WDR77USP2SMN1; SMN2 | |
| SCHEMBL22907261 | 0.87 | NR1H2 (0.46) | NR1H2PRMT5WDR77USP2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230250097-A1 | BENZO[C][2,6]NAPHTHYRIDINE DERIVATIVES, COMPOSITIONS AND THERAPEUTIC USES THEREOF | Apollo Therapeutics Limited (GB) | 2023-08-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230250097-A1 | BENZO[C][2,6]NAPHTHYRIDINE DERIVATIVES, COMPOSITIONS AND THERAPEUTIC USES THEREOF | CSNK1A1, CSNK1D, CSNK2A1 | NR1H2 658/4885PRMT5 2375/4885WDR77 2418/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.