Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 3/20 | 0.43 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.43 |
| ▸ | PI4KA | P42356 | 1/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.43 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.43 |
| ▸ | P2RX3 | P56373 | 12/20 | 0.41 |
| ▸ | P2RX2 | Q9UBL9 | 12/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
| ▸ | MTOR | P42345 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26066976 | 0.80 | IDH1 (0.44) | PIK3CAPI4KBPIK3CDPIK3CBPI4KA | |
| SCHEMBL3057476 | 0.79 | NPC1 (0.43) | — | |
| SCHEMBL26848733 | 0.78 | PIK3CA (0.45) | PIK3CAPI4KBPIK3CDPIK3CBPI4KA | |
| SCHEMBL16089000 | 0.77 | PIK3CA (0.45) | PIK3CAPI4KBPIK3CDPIK3CBPI4KA | |
| SCHEMBL31596094 | 0.76 | PIK3CA (0.41) | PIK3CAPI4KBPIK3CDPIK3CBPI4KA | |
| SCHEMBL16088951 | 0.76 | PIK3CA (0.41) | PIK3CAPI4KBPIK3CDPIK3CBPI4KA | |
| SCHEMBL26848732 | 0.75 | PIK3CA (0.43) | PIK3CAPI4KBPIK3CDPIK3CBPI4KA | |
| SCHEMBL30908151 | 0.75 | HDAC1 (0.51) | PIK3CAPI4KBPIK3CDPIK3CBPI4KA | |
| SCHEMBL13680533 | 0.74 | CYP2E1 (0.50) | PIK3CAPI4KBPIK3CDPIK3CBPI4KA | |
| SCHEMBL17589831 | 0.74 | NPC1 (0.44) | PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023164237-A1 | COMPOUNDS AND METHODS USEFUL FOR STABILIZING PHENYLALANINE HYDROXYLASE MUTATIONS | AGIOS PHARMACEUTICALS, INC. (US) | 2023-08-31 | — | — | WO | disclosed |