Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 19/20 | 0.74 |
| ▸ | JAK1 | P23458 | 18/20 | 0.74 |
| ▸ | JAK3 | P52333 | 14/20 | 0.74 |
| ▸ | CIT | O14578 | 1/20 | 0.71 |
| ▸ | GAK | O14976 | 1/20 | 0.71 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.71 |
| ▸ | ULK1 | O75385 | 1/20 | 0.71 |
| ▸ | PRKCB | P05771 | 1/20 | 0.71 |
| ▸ | RET | P07949 | 1/20 | 0.71 |
| ▸ | PRKCA | P17252 | 1/20 | 0.71 |
| ▸ | PRKACA | P17612 | 1/20 | 0.71 |
| ▸ | MARK3 | P27448 | 1/20 | 0.71 |
| ▸ | TYK2 | P29597 | 1/20 | 0.71 |
| ▸ | STAT3 | P40763 | 1/20 | 0.71 |
| ▸ | CLK1 | P49759 | 1/20 | 0.71 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.71 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.71 |
| ▸ | MAP3K1 | Q13233 | 1/20 | 0.71 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.71 |
| ▸ | TNK1 | Q13470 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL16007893 | 0.99 | JAK2 (0.72) | JAK2JAK1JAK3CITGAK | |
| Hydrochloric Acid SCHEMBL29395202 | 0.99 | JAK2 (0.72) | JAK2JAK1JAK3CITGAK | |
| SCHEMBL29541207 | 0.91 | JAK2 (0.83) | JAK2JAK1JAK3CITGAK | |
| SCHEMBL100609 | 0.91 | JAK2 (0.83) | JAK2JAK1JAK3CITGAK | |
| Trifluoroacetic Acid SCHEMBL871919 | 0.91 | JAK2 (0.65) | JAK2JAK1JAK3CITGAK | |
| Trifluoroacetic Acid SCHEMBL870688 | 0.91 | JAK2 (0.65) | JAK2JAK1JAK3CITGAK | |
| SCHEMBL102406 | 0.90 | JAK2 (0.77) | JAK2JAK1JAK3CITGAK | |
| SCHEMBL871842 | 0.89 | JAK2 (0.80) | JAK2JAK1JAK3CITGAK | |
| SCHEMBL100359 | 0.89 | JAK2 (0.83) | JAK2JAK1JAK3CITGAK | |
| Tert-Butyl Formate SCHEMBL28050500 | 0.89 | JAK2 (0.66) | JAK2JAK1JAK3CITGAK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3715347-B1 | PIPERIDIN-4-YL AZETIDINE DERIVATIVES AS JAK1 INHIBITORS | INCYTE HOLDINGS CORP (US) | 2021-12-22 | — | — | EP | claimed |
| EP-2964650-B1 | PROCESSES AND INTERMEDIATES FOR MAKING A JAK INHIBITOR | INCYTE HOLDINGS CORP (US) | 2018-12-05 | — | — | EP | claimed |
| EP-2545045-B1 | PIPERIDIN-4-YL AZETIDINE DERIVATIVES AS JAK1 INHIBITORS | INCYTE HOLDINGS CORP (US) | 2016-01-06 | — | — | EP | claimed |
| EP-4400172-A2 | PIPERIDIN-4-YL AZETIDINE DERIVATIVES AS JAK1 INHIBITORS | Incyte Holdings Corporation (US) | 2024-07-17 | — | — | EP | disclosed |
| US-11654143-B2 | Therapeutic combinations of a BTK inhibitor, a PI3K inhibitor, a JAK-2 inhibitor, and/or a BCL-2 inhibitor | ACERTA PHARMA B.V. (NL) | 2023-05-23 | — | — | US | disclosed |
| EP-3985008-A1 | PROCESSES AND INTERMEDIATES FOR MAKING A JAK INHIBITOR | Incyte Holdings Corporation (US) | 2022-04-20 | — | — | EP | disclosed |
| US-20220056034-A1 | PROCESS AND INTERMEDIATES FOR PREPARING A JAK1 INHIBITOR | INCYTE CORPORATION | 2022-02-24 | — | — | US | disclosed |
| WO-2021254133-A1 | SMALL MOLECULE COMPOUND | 嘉兴特科罗生物科技有限公司 | 2021-12-23 | — | — | WO | disclosed |
| EP-3715347-B1 | PIPERIDIN-4-YL AZETIDINE DERIVATIVES AS JAK1 INHIBITORS | INCYTE HOLDINGS CORP (US) | 2021-12-22 | — | — | EP | disclosed |
| EP-3489239-B1 | PROCESSES AND INTERMEDIATES FOR MAKING A JAK INHIBITOR | INCYTE HOLDINGS CORP (US) | 2021-09-15 | — | — | EP | disclosed |
| WO-2021053690-A1 | AN IMPROVED PROCESS FOR THE PREPARATION OF BARICITINIB | NATCO PHARMA LIMITED (IN) | 2021-03-25 | — | — | WO | disclosed |
| WO-2013026025-A1 | CYCLOHEXYL AZETIDINE DERIVATIVES AS JAK INHIBITORS | INCYTE CORPORATION (US) | 2013-02-21 | — | — | WO | disclosed |
| US-8158616-B2 | Azetidine and cyclobutane derivatives as JAK inhibitors | INCYTE CORPORATION (US) | 2012-04-17 | — | — | US | disclosed |
| US-8158616-B2 | Azetidine and cyclobutane derivatives as JAK inhibitors | INCYTE CORPORATION (US) | 2012-04-17 | — | — | US | disclosed |
| US-20120077798-A1 | AZETIDINE AND CYCLOBUTANE DERIVATIVES AS JAK INHIBITORS | INCYTE CORPORATION | 2012-03-29 | — | — | US | disclosed |
| US-20120077798-A1 | AZETIDINE AND CYCLOBUTANE DERIVATIVES AS JAK INHIBITORS | INCYTE CORPORATION | 2012-03-29 | — | — | US | disclosed |
| WO-2011112662-A1 | PIPERIDIN-4-YL AZETIDINE DERIVATIVES AS JAK1 INHIBITORS | INCYTE CORPORATION (US) | 2011-09-15 | — | — | WO | disclosed |
| WO-2009114512-A1 | AZETIDINE AND CYCLOBUTANE DERIVATIVES AS JAK INHIBITORS | INCYTE CORPORATION (US) | 2009-09-17 | — | — | WO | disclosed |
| US-20090233903-A1 | AZETIDINE AND CYCLOBUTANE DERIVATIVES AS JAK INHIBITORS | INCYTE CORPORATION (US) | 2009-09-17 | — | — | US | disclosed |
| US-20090233903-A1 | AZETIDINE AND CYCLOBUTANE DERIVATIVES AS JAK INHIBITORS | INCYTE CORPORATION (US) | 2009-09-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220056034-A1 | PROCESS AND INTERMEDIATES FOR PREPARING A JAK1 INHIBITOR | JAK1, JAK2, JAK3 | JAK2 2/4885JAK1 1/4885JAK3 3/4885 |
| US-11654143-B2 | Therapeutic combinations of a BTK inhibitor, a PI3K inhibitor, a JAK-2 inhibitor, and/or a BCL-2 inhibitor | BTK, JAK2, BCL9 | JAK2 2/4885JAK1 5/4885JAK3 8/4885 |
| US-20090233903-A1 | AZETIDINE AND CYCLOBUTANE DERIVATIVES AS JAK INHIBITORS | JAK1, JAK2, JAK3 | JAK2 2/4885JAK1 1/4885JAK3 3/4885 |
| US-20120077798-A1 | AZETIDINE AND CYCLOBUTANE DERIVATIVES AS JAK INHIBITORS | JAK1, JAK2, JAK3 | JAK2 2/4885JAK1 1/4885JAK3 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.