Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 14/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 8/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.35 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.33 |
| ▸ | WDR77 | Q9BQA1 | 3/20 | 0.33 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.33 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.32 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.32 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.32 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.32 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26052031 | 0.93 | HDAC6 (0.35) | HDAC6HDAC1HDAC3HDAC2PRMT5 | |
| SCHEMBL26056261 | 0.89 | HDAC6 (0.39) | HDAC6HDAC1HDAC3HDAC2ABCB1 | |
| SCHEMBL26056262 | 0.85 | HDAC6 (0.38) | HDAC6HDAC1HDAC3HDAC2HDAC4 | |
| SCHEMBL26063068 | 0.83 | HDAC6 (0.35) | HDAC6HDAC1HDAC3HDAC2HDAC4 | |
| SCHEMBL26051970 | 0.82 | HDAC6 (0.36) | HDAC6HDAC1HDAC3HDAC2ABCB1 | |
| SCHEMBL26055254 | 0.82 | HDAC6 (0.45) | HDAC6HDAC1HDAC3HDAC2HDAC4 | |
| SCHEMBL26055722 | 0.81 | HDAC6 (0.31) | HDAC6HDAC1HDAC3HDAC2HDAC4 | |
| SCHEMBL26055720 | 0.81 | HDAC6 (0.31) | HDAC6HDAC1HDAC3HDAC2HDAC4 | |
| SCHEMBL26063067 | 0.79 | HDAC6 (0.40) | HDAC6HDAC1HDAC3HDAC2PRMT5 | |
| SCHEMBL26055253 | 0.79 | HDAC6 (0.41) | HDAC6HDAC1HDAC3HDAC2ABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023150203-A1 | HDAC6 INHIBITORS AND USES THEREOF | EIKONIZO THERAPEUTICS, INC. (US) | 2023-08-10 | — | — | WO | disclosed |