Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 2/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 6/20 | 0.34 |
| ▸ | RXRA | P19793 | 4/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 4/20 | 0.34 |
| ▸ | JAK2 | O60674 | 2/20 | 0.33 |
| ▸ | JAK1 | P23458 | 2/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 2/20 | 0.31 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.31 |
| ▸ | CCR2 | P41597 | 1/20 | 0.31 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.31 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26057789 | 1.00 | ACACB (0.36) | ACACBNR1H2RXRANR1H3JAK2 | |
| SCHEMBL26057783 | 1.00 | ACACB (0.36) | ACACBNR1H2RXRANR1H3JAK2 | |
| SCHEMBL30623236 | 0.89 | ACACB (0.34) | ACACBNR1H2RXRANR1H3JAK2 | |
| SCHEMBL31387347 | 0.89 | ACACB (0.34) | ACACBNR1H2RXRANR1H3JAK2 | |
| SCHEMBL26058252 | 0.89 | ACACB (0.34) | ACACBNR1H2RXRANR1H3JAK2 | |
| SCHEMBL30623258 | 0.89 | ACACB (0.34) | ACACBNR1H2RXRANR1H3JAK2 | |
| SCHEMBL31387420 | 0.89 | JAK2 (0.34) | ACACBNR1H2RXRANR1H3JAK2 | |
| SCHEMBL31387468 | 0.89 | ACACB (0.34) | ACACBNR1H2RXRANR1H3JAK2 | |
| SCHEMBL30623318 | 0.89 | JAK2 (0.34) | ACACBNR1H2RXRANR1H3JAK2 | |
| SCHEMBL30623337 | 0.89 | ACACB (0.34) | ACACBNR1H2RXRANR1H3JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023154344-A1 | 2-METHYL-4',5'-DIHYDROSPIRO[PIPERIDINE-4,7'-THIENO[2,3-C]PYRAN] DERIVATIVES AS INHIBITORS OF APOL1 AND METHODS OF USING SAME | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2023-08-17 | — | — | WO | disclosed |