Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.67 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.64 |
| ▸ | HPGD | P15428 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 10/20 | 0.61 |
| ▸ | MEN1 | O00255 | 8/20 | 0.61 |
| ▸ | RAB9A | P51151 | 4/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.56 |
| ▸ | NPC1 | O15118 | 4/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.56 |
| ▸ | HTT | P42858 | 4/20 | 0.51 |
| ▸ | POLB | P06746 | 3/20 | 0.51 |
| ▸ | DDX3X | O00571 | 1/20 | 0.51 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL260595 | 1.00 | MAPT (0.67) | MAPTALOX12ALDH1A1HPGDKMT2A | |
| SCHEMBL1465069 | 0.80 | MAPT (0.67) | MAPTALOX12ALDH1A1HPGDKMT2A | |
| SCHEMBL1465067 | 0.80 | MAPT (0.67) | MAPTALOX12ALDH1A1HPGDKMT2A | |
| SCHEMBL11997899 | 0.80 | MAPT (0.67) | MAPTALOX12ALDH1A1HPGDKMT2A | |
| SCHEMBL1465068 | 0.80 | MAPT (0.67) | MAPTALOX12ALDH1A1HPGDKMT2A | |
| SCHEMBL9068138 | 0.79 | MAPT (0.65) | MAPTALOX12ALDH1A1HPGDKMT2A | |
| SCHEMBL9068136 | 0.79 | MAPT (0.65) | MAPTALOX12ALDH1A1HPGDKMT2A | |
| SCHEMBL8657109 | 0.78 | MAPT (0.64) | MAPTALOX12ALDH1A1HPGDKMT2A | |
| SCHEMBL923440 | 0.75 | MAPT (0.68) | MAPTALOX12ALDH1A1HPGDKMT2A | |
| SCHEMBL1507727 | 0.75 | MAPT (0.57) | MAPTALOX12ALDH1A1HPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8163752-B2 | Tricyclic anilide heterocyclic CGRP receptor antagonists | Merck, Sharp & Dohme Corp. (US) | 2012-04-24 | — | — | US | disclosed |
| US-8133891-B2 | Tricyclic anilide spirolactam CGRP receptor antagonists | Merck, Sharp & Dohme Corp. (US) | 2012-03-13 | — | — | US | disclosed |