Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.57 |
| ▸ | RAB9A | P51151 | 6/20 | 0.50 |
| ▸ | NPC1 | O15118 | 5/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 2/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | CHKA | P35790 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | Q9HBH1 | 1/20 | 0.38 | |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1002294 | 0.92 | SMN1; SMN2 (0.63) | SMN1; SMN2RAB9ANPC1GAAMEN1 | |
| SCHEMBL2653739 | 0.91 | SMN1; SMN2 (0.51) | SMN1; SMN2RAB9ANPC1GAAMEN1 | |
| SCHEMBL2649136 | 0.87 | SMN1; SMN2 (0.55) | SMN1; SMN2RAB9ANPC1GAAMEN1 | |
| SCHEMBL998432 | 0.86 | SMN1; SMN2 (0.52) | SMN1; SMN2RAB9ANPC1GAAMEN1 | |
| SCHEMBL2666146 | 0.86 | SMN1; SMN2 (0.52) | SMN1; SMN2RAB9ANPC1GAAMEN1 | |
| SCHEMBL999778 | 0.86 | SMN1; SMN2 (0.56) | SMN1; SMN2RAB9ANPC1GAAMEN1 | |
| SCHEMBL999495 | 0.86 | SMN1; SMN2 (0.56) | SMN1; SMN2RAB9ANPC1GAAMEN1 | |
| SCHEMBL998509 | 0.85 | SMN1; SMN2 (0.55) | SMN1; SMN2RAB9ANPC1GAAMEN1 | |
| SCHEMBL999145 | 0.83 | SMN1; SMN2 (0.57) | SMN1; SMN2RAB9ANPC1GAAMEN1 | |
| SCHEMBL998383 | 0.83 | SMN1; SMN2 (0.55) | SMN1; SMN2RAB9ANPC1GAAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2444397-A1 | Heteroaryl-ureas and their use as glucokinase activators | Novo Nordisk A/S (DK) | 2012-04-25 | — | — | EP | disclosed |