Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 5/20 | 0.41 |
| ▸ | CCNE2 | O96020 | 4/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.41 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | CDK4 | P11802 | 1/20 | 0.41 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.41 |
| ▸ | CCND1 | P24385 | 1/20 | 0.41 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ITK | Q08881 | 10/20 | 0.40 |
| ▸ | BMX | P51813 | 1/20 | 0.37 |
| ▸ | BTK | Q06187 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL999340 | 0.89 | MAPT (0.50) | MAPTMAPK1HTTCDK2CCNE2 | |
| SCHEMBL1000071 | 0.87 | MAPT (0.48) | MAPTMAPK1HTTCDK2CCNE2 | |
| SCHEMBL1000624 | 0.87 | MAPT (0.48) | MAPTMAPK1HTTCDK2CCNE2 | |
| SCHEMBL1000552 | 0.87 | MAPT (0.48) | MAPTMAPK1HTTCDK2CCNE2 | |
| SCHEMBL1000427 | 0.85 | MAPT (0.50) | MAPTMAPK1HTTCDK2CCNE2 | |
| SCHEMBL1000598 | 0.85 | MAPT (0.50) | MAPTMAPK1HTTCDK2CCNE2 | |
| SCHEMBL1000120 | 0.84 | MAPT (0.49) | MAPTMAPK1HTTCDK2CCNE2 | |
| SCHEMBL999470 | 0.84 | MAPT (0.52) | MAPTMAPK1HTTCDK2CCNE2 | |
| SCHEMBL1000949 | 0.84 | MAPT (0.45) | MAPTMAPK1HTTCDK2CCNE2 | |
| SCHEMBL1000137 | 0.83 | CDK1 (0.57) | MAPTMAPK1HTTCDK2CCNE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2444397-A1 | Heteroaryl-ureas and their use as glucokinase activators | Novo Nordisk A/S (DK) | 2012-04-25 | — | — | EP | disclosed |