Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1H | O95180 | 7/20 | 0.39 |
| ▸ | CACNA1I | Q9P0X4 | 4/20 | 0.39 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.39 |
| ▸ | F10 | P00742 | 3/20 | 0.36 |
| ▸ | PDE4A | P27815 | 4/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26082026 | 0.93 | CACNA1H (0.47) | CACNA1HCACNA1ICACNA1GF10PDE4A | |
| SCHEMBL26082038 | 0.90 | CACNA1H (0.39) | CACNA1HCACNA1ICACNA1GF10PDE4A | |
| SCHEMBL26083480 | 0.87 | CACNA1I (0.53) | CACNA1HCACNA1ICACNA1GF10KCNH2 | |
| SCHEMBL26541960 | 0.83 | CACNA1H (0.50) | CACNA1HCACNA1ICACNA1GF10PDE4A | |
| SCHEMBL26082103 | 0.82 | PDE4A (0.38) | CACNA1HCACNA1ICACNA1GF10PDE4A | |
| SCHEMBL26082099 | 0.82 | PDE4A (0.38) | CACNA1HCACNA1ICACNA1GF10PDE4A | |
| SCHEMBL26081910 | 0.81 | CACNA1H (0.41) | CACNA1HCACNA1ICACNA1GKCNH2 | |
| SCHEMBL26083463 | 0.79 | CACNA1I (0.62) | CACNA1HCACNA1ICACNA1GF10KCNH2 | |
| SCHEMBL26082028 | 0.78 | CACNA1H (0.43) | CACNA1HCACNA1ICACNA1G | |
| SCHEMBL26083479 | 0.77 | CACNA1I (0.53) | CACNA1HCACNA1ICACNA1GF10KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023192687-A1 | T-TYPE CALCIUM CHANNEL MODULATORS COMPRISING AN AZASPIROHEPTANE CORE AND METHODS OF USE THEREOF | PRAXIS PRECISION MEDICINES, INC. (US) | 2023-10-05 | — | — | WO | disclosed |