Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1I | Q9P0X4 | 5/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.45 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.44 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.44 |
| ▸ | F10 | P00742 | 11/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26082105 | 1.00 | CACNA1I (0.45) | CACNA1IKCNH2CACNA1HCACNA1GF10 | |
| SCHEMBL26083561 | 1.00 | CACNA1I (0.45) | CACNA1IKCNH2CACNA1HCACNA1GF10 | |
| SCHEMBL26082099 | 0.87 | PDE4A (0.38) | CACNA1ICACNA1HCACNA1GF10PDE4A | |
| SCHEMBL26082103 | 0.87 | PDE4A (0.38) | CACNA1ICACNA1HCACNA1GF10PDE4A | |
| SCHEMBL26083463 | 0.85 | CACNA1I (0.62) | CACNA1IKCNH2CACNA1HCACNA1GF10 | |
| SCHEMBL26082102 | 0.83 | CACNA1H (0.51) | CACNA1IKCNH2CACNA1HCACNA1GALDH1A1 | |
| SCHEMBL26082097 | 0.83 | CACNA1H (0.51) | CACNA1IKCNH2CACNA1HCACNA1GALDH1A1 | |
| SCHEMBL26082106 | 0.83 | CACNA1H (0.51) | CACNA1IKCNH2CACNA1HCACNA1GALDH1A1 | |
| SCHEMBL26541958 | 0.80 | CACNA1H (0.48) | CACNA1ICACNA1HCACNA1GF10PDE4A | |
| SCHEMBL26541957 | 0.80 | CACNA1H (0.48) | CACNA1ICACNA1HCACNA1GF10PDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023192687-A1 | T-TYPE CALCIUM CHANNEL MODULATORS COMPRISING AN AZASPIROHEPTANE CORE AND METHODS OF USE THEREOF | PRAXIS PRECISION MEDICINES, INC. (US) | 2023-10-05 | — | — | WO | disclosed |