⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1133019 | 0.78 | SLC6A4 (0.34) | — | |
| SCHEMBL8444024 | 0.75 | DPP4 (0.34) | — | |
| SCHEMBL21510160 | 0.72 | — | — | |
| SCHEMBL13283760 | 0.72 | — | — | |
| SCHEMBL18506404 | 0.71 | — | — | |
| SCHEMBL5986694 | 0.71 | — | — | |
| SCHEMBL13599967 | 0.69 | — | — | |
| SCHEMBL13640555 | 0.69 | EPHX2 (0.32) | — | |
| SCHEMBL17562003 | 0.67 | — | — | |
| SCHEMBL12126139 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3843850-B1 | PYRAZOLO[3,4-B]PYRIDINE COMPOUNDS AS INHIBITORS OF TAM AND MET KINASES | ARRAY BIOPHARMA INC (US) | 2023-11-15 | — | — | EP | disclosed |
| US-11780835-B2 | Pyrazolo[3,4-b]pyridine compounds as inhibitors of TAM and MET kinases | ARRAY BIOPHARMA INC. (US) | 2023-10-10 | — | — | US | disclosed |