⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15967533 | 0.77 | — | — | |
| SCHEMBL23127343 | 0.72 | — | — | |
| SCHEMBL10291294 | 0.70 | — | — | |
| SCHEMBL26084137 | 0.65 | — | — | |
| SCHEMBL2138807 | 0.65 | SMN1; SMN2 (0.34) | — | |
| SCHEMBL11987188 | 0.65 | — | — | |
| SCHEMBL11897723 | 0.65 | — | — | |
| SCHEMBL26084117 | 0.65 | — | — | |
| SCHEMBL14118469 | 0.62 | — | — | |
| SCHEMBL26207648 | 0.62 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11873305-B2 | Processes for synthesis of substituted indole intermediates for the synthesis of serd compounds | GENENTECH, INC. (US) | 2024-01-16 | — | — | US | disclosed |
| US-11780834-B2 | Solid forms of 3-((1R,3R)-1-(2,6-difluoro-4-((1-(3-fluoropropyl)azetidin-3- yl)amino)phenyl)-3-methyl-1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indol-2-yl)-2,2-difluoropropan-1-ol and processes for preparing fused tricyclic compounds comprising a substituted phenyl or pyridinyl moiety, including methods of their use | GENENTECH, INC. (US) | 2023-10-10 | — | — | US | disclosed |