Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 5/20 | 0.64 |
| ▸ | CA12 | O43570 | 3/20 | 0.53 |
| ▸ | CA1 | P00915 | 3/20 | 0.53 |
| ▸ | CA2 | P00918 | 3/20 | 0.53 |
| ▸ | CA9 | Q16790 | 3/20 | 0.53 |
| ▸ | WDR5 | P61964 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | ESRRA | P11474 | 1/20 | 0.45 |
| ▸ | RXRA | P19793 | 1/20 | 0.45 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.45 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12571599 | 0.80 | CA1 (0.64) | NOTUMCA12CA1CA2CA9 | |
| SCHEMBL21776821 | 0.79 | NOTUM (0.75) | NOTUMCA12CA1CA2CA9 | |
| SCHEMBL21792125 | 0.78 | NOTUM (1.00) | NOTUMCA12CA1CA2CA9 | |
| SCHEMBL12571591 | 0.76 | CA12 (0.66) | NOTUMCA12CA1CA2CA9 | |
| SCHEMBL18298398 | 0.75 | NOTUM (0.50) | NOTUMCA12CA1CA2CA9 | |
| SCHEMBL29739246 | 0.75 | NOTUM (0.50) | NOTUMCA12CA1CA2CA9 | |
| SCHEMBL21777017 | 0.75 | NOTUM (1.00) | NOTUMCA12CA1CA2CA9 | |
| SCHEMBL16065310 | 0.75 | NOTUM (0.47) | NOTUMCA12CA1CA2CA9 | |
| SCHEMBL14788707 | 0.73 | CA1 (0.67) | NOTUMCA12CA1CA2CA9 | |
| SCHEMBL12571597 | 0.73 | CA12 (0.55) | NOTUMCA12CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3307727-B1 | HETEROCYCLIC INHIBITORS OF ERK1 AND ERK2 AND THEIR USE IN THE TREATMENT OF CANCER | ASANA BIOSCIENCES LLC (US) | 2023-10-04 | — | — | EP | disclosed |