Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 2/20 | 0.65 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.65 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.65 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.65 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.65 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.65 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.65 |
| ▸ | JAK2 | O60674 | 3/20 | 0.40 |
| ▸ | BTK | Q06187 | 2/20 | 0.37 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 4/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.35 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.34 |
| ▸ | MET | P08581 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22676821 | 0.89 | FGFR1 (0.81) | FGFR1FGFR2FGFR4FGFR3CYP3A4 | |
| SCHEMBL22675831 | 0.83 | FGFR1 (0.62) | FGFR1FGFR2FGFR4FGFR3CYP3A4 | |
| SCHEMBL30303551 | 0.83 | FGFR1 (0.62) | FGFR1FGFR2FGFR4FGFR3CYP3A4 | |
| SCHEMBL22676823 | 0.81 | FGFR1 (0.78) | FGFR1FGFR2FGFR4FGFR3CYP3A4 | |
| SCHEMBL22677855 | 0.81 | FGFR1 (0.78) | FGFR1FGFR2FGFR4FGFR3CYP3A4 | |
| SCHEMBL30303429 | 0.81 | FGFR1 (0.78) | FGFR1FGFR2FGFR4FGFR3CYP3A4 | |
| SCHEMBL22676511 | 0.81 | BTK (0.51) | FGFR1FGFR2FGFR4FGFR3CYP3A4 | |
| SCHEMBL26085971 | 0.80 | FGFR1 (0.64) | FGFR1FGFR2FGFR4FGFR3CYP3A4 | |
| SCHEMBL22676895 | 0.79 | FGFR1 (0.86) | FGFR1FGFR2FGFR4FGFR3CYP3A4 | |
| Lirafugratinib SCHEMBL30303579 | 0.79 | FGFR1 (1.00) | FGFR1FGFR2FGFR4FGFR3CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11780845-B2 | FGFR inhibitors and methods of use thereof | RELAY THERAPEUTICS, INC. (US) | 2023-10-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11780845-B2 | FGFR inhibitors and methods of use thereof | FGFR3, FGFR2, FGFR1 | FGFR1 3/4885FGFR2 2/4885FGFR4 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.