Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 6/20 | 0.46 |
| ▸ | BTK | Q06187 | 13/20 | 0.43 |
| ▸ | EGFR | P00533 | 7/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.42 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.42 |
| ▸ | TEC | P42680 | 3/20 | 0.42 |
| ▸ | BMX | P51813 | 3/20 | 0.42 |
| ▸ | TXK | P42681 | 2/20 | 0.42 |
| ▸ | LYN | P07948 | 2/20 | 0.42 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.42 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.42 |
| ▸ | BLK | P51451 | 2/20 | 0.42 |
| ▸ | JAK3 | P52333 | 2/20 | 0.42 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.42 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.42 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.42 |
| ▸ | LATS1 | O95835 | 1/20 | 0.42 |
| ▸ | NUDT14 | O95848 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22677237 | 0.89 | ITK (0.51) | ITKBTKEGFRFGFR1FGFR4 | |
| SCHEMBL22676899 | 0.88 | ITK (0.50) | ITKBTKEGFRFGFR1FGFR4 | |
| SCHEMBL22676277 | 0.88 | ITK (0.50) | ITKBTKEGFRFGFR1FGFR4 | |
| SCHEMBL30303563 | 0.88 | ITK (0.50) | ITKBTKEGFRFGFR1FGFR4 | |
| SCHEMBL22676560 | 0.86 | ITK (0.48) | ITKBTKEGFRFGFR1FGFR4 | |
| SCHEMBL30303844 | 0.86 | ITK (0.48) | ITKBTKEGFRFGFR1FGFR4 | |
| SCHEMBL25129352 | 0.85 | ITK (0.44) | ITKBTKEGFRFGFR1FGFR4 | |
| SCHEMBL22676206 | 0.84 | ITK (0.60) | ITKBTKFGFR1FGFR4FGFR2 | |
| SCHEMBL22676404 | 0.81 | ITK (0.49) | ITKBTKEGFRFGFR1FGFR4 | |
| SCHEMBL22673414 | 0.81 | EGFR (0.56) | ITKBTKEGFRFGFR1FGFR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11780845-B2 | FGFR inhibitors and methods of use thereof | RELAY THERAPEUTICS, INC. (US) | 2023-10-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11780845-B2 | FGFR inhibitors and methods of use thereof | FGFR3, FGFR2, FGFR1 | ITK 1273/4885BTK 39/4885EGFR 16/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.