Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 18/20 | 0.49 |
| ▸ | BRAF | P15056 | 2/20 | 0.38 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.37 |
| ▸ | MTOR | P42345 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30378784 | 1.00 | RAF1 (0.49) | RAF1BRAFPIK3R1PIK3CAMTOR | |
| SCHEMBL26090219 | 0.91 | RAF1 (0.42) | RAF1BRAFPIK3R1PIK3CAMTOR | |
| SCHEMBL30377975 | 0.91 | RAF1 (0.42) | RAF1BRAFPIK3R1PIK3CAMTOR | |
| SCHEMBL30379136 | 0.88 | RAF1 (0.50) | RAF1BRAFPIK3R1PIK3CAMTOR | |
| SCHEMBL26087687 | 0.88 | RAF1 (0.50) | RAF1BRAFPIK3R1PIK3CAMTOR | |
| SCHEMBL30378771 | 0.86 | BRAF (0.45) | RAF1BRAFPIK3R1PIK3CAMTOR | |
| SCHEMBL26090580 | 0.86 | BRAF (0.45) | RAF1BRAFPIK3R1PIK3CAMTOR | |
| SCHEMBL24312209 | 0.84 | RAF1 (0.58) | RAF1BRAF | |
| SCHEMBL29610432 | 0.84 | RAF1 (0.58) | RAF1BRAF | |
| SCHEMBL24319054 | 0.78 | RAF1 (0.63) | RAF1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023070053-A1 | INHIBITORS OF RAF KINASES | KINNATE BIOPHARMA INC. (US) | 2023-04-27 | — | — | WO | disclosed |
| WO-2023070053-A1 | INHIBITORS OF RAF KINASES | KINNATE BIOPHARMA INC. (US) | 2023-04-27 | — | — | WO | disclosed |