Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.48 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.48 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.44 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30407340 | 0.85 | CYP2D6 (0.48) | NPC1RAB9AHTTHDAC6ERCC1 | |
| SCHEMBL26425799 | 0.85 | CYP2D6 (0.48) | NPC1RAB9AHTTHDAC6ERCC1 | |
| SCHEMBL26423835 | 0.84 | NPC1 (0.47) | NPC1RAB9AHTTHDAC6PTGER4 | |
| SCHEMBL26090158 | 0.83 | HTT (0.61) | NPC1RAB9AHTTHDAC6ERCC1 | |
| SCHEMBL26090397 | 0.81 | NPC1 (0.63) | NPC1RAB9AHTTHDAC6ERCC1 | |
| SCHEMBL26090239 | 0.81 | HTT (0.63) | NPC1RAB9AHTTHDAC6ERCC1 | |
| SCHEMBL26425647 | 0.81 | NPC1 (0.63) | NPC1RAB9AHTTERCC1ERCC4 | |
| SCHEMBL26090394 | 0.80 | NPC1 (0.53) | NPC1RAB9AHTTHDAC6ERCC1 | |
| SCHEMBL26136371 | 0.80 | HTT (0.61) | NPC1RAB9AHTTHDAC6ERCC1 | |
| SCHEMBL31024154 | 0.80 | NPC1 (0.55) | NPC1RAB9AHTTHDAC6ERCC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023069721-A2 | OXAZOLE, OXADIAZOLE, AND INDOLE DERIVATIVES FOR THE INHIBITION OF USP28 | CARMOT THERAPEUTICS, INC. (US) | 2023-04-27 | — | — | WO | disclosed |